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2pla
From Proteopedia
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| - | [[Image:2pla.jpg|left|200px]]<br /><applet load="2pla" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2pla, resolution 2.510Å" /> | ||
| - | '''Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein'''<br /> | ||
| - | == | + | ==Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein== |
| - | + | <StructureSection load='2pla' size='340' side='right'caption='[[2pla]], [[Resolution|resolution]] 2.51Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[2pla]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PLA FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pla OCA], [https://pdbe.org/2pla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pla RCSB], [https://www.ebi.ac.uk/pdbsum/2pla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pla ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Brugada syndrome. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GPD1L_HUMAN GPD1L_HUMAN] Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.<ref>PMID:19666841</ref> <ref>PMID:19745168</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/2pla_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pla ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bunkoczi | + | [[Category: Bunkoczi G]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Hozjan V]] |
| - | [[Category: Hozjan | + | [[Category: Kavanagh K]] |
| - | [[Category: Kavanagh | + | [[Category: Oppermann U]] |
| - | [[Category: Oppermann | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Pike ACW]] |
| - | [[Category: Pike | + | [[Category: Smee C]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Smee | + | [[Category: Ugochukwu E]] |
| - | [[Category: Sundstrom | + | [[Category: Umeano C]] |
| - | [[Category: Ugochukwu | + | [[Category: Uppenberg J]] |
| - | [[Category: Umeano | + | [[Category: Weigelt J]] |
| - | [[Category: Uppenberg | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of human glycerol-3-phosphate dehydrogenase 1-like protein
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bunkoczi G | Edwards A | Hozjan V | Kavanagh K | Oppermann U | Papagrigoriou E | Pike ACW | Smee C | Sundstrom M | Ugochukwu E | Umeano C | Uppenberg J | Weigelt J | Von Delft F
