4n9f
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex== | |
| + | <StructureSection load='4n9f' size='340' side='right'caption='[[4n9f]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4n9f]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9f OCA], [https://pdbe.org/4n9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9f RCSB], [https://www.ebi.ac.uk/pdbsum/4n9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CUL5_HUMAN CUL5_HUMAN] Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. | ||
| - | + | ==See Also== | |
| - | + | *[[Core-binding factor|Core-binding factor]] | |
| - | + | *[[Cullin 3D structures|Cullin 3D structures]] | |
| + | *[[Elongation factor 3D structures|Elongation factor 3D structures]] | ||
| + | *[[Virion infectivity factor|Virion infectivity factor]] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dong LY]] | ||
| + | [[Category: Guo YY]] | ||
| + | [[Category: Huang ZW]] | ||
Current revision
Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex
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