This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2mf9
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_2mf9| PDB=2mf9 | SCENE= }} | ||
| - | ===Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD)=== | ||
| - | {{ABSTRACT_PUBMED_24145868}} | ||
| - | == | + | ==Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD)== |
| - | [[http://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN | + | <StructureSection load='2mf9' size='340' side='right'caption='[[2mf9]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mf9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jwx 2jwx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MF9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MF9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mf9 OCA], [https://pdbe.org/2mf9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mf9 RCSB], [https://www.ebi.ac.uk/pdbsum/2mf9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mf9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[FKBP 3D structures|FKBP 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Kang | + | [[Category: Kang C]] |
| - | [[Category: Sattler | + | [[Category: Sattler M]] |
| - | [[Category: Simon | + | [[Category: Simon B]] |
| - | [[Category: Ye | + | [[Category: Ye H]] |
| - | [[Category: Yoon | + | [[Category: Yoon HS]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD)
| |||||||||||
Categories: Homo sapiens | Large Structures | Kang C | Sattler M | Simon B | Ye H | Yoon HS
