3w0t

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{{STRUCTURE_3w0t| PDB=3w0t | SCENE= }}
 
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===Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor===
 
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==Function==
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==Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor==
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[[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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<StructureSection load='3w0t' size='340' side='right'caption='[[3w0t]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3w0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.351&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=HPU:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDROPYRIDIN-2-YL)PHENYL]METHANESULFONAMIDE'>HPU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0t OCA], [https://pdbe.org/3w0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0t RCSB], [https://www.ebi.ac.uk/pdbsum/3w0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref>
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==About this Structure==
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==See Also==
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[[3w0t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0T OCA].
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*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lactoylglutathione lyase]]
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[[Category: Large Structures]]
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[[Category: Fukami, T A.]]
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[[Category: Fukami TA]]
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[[Category: Irie, M.]]
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[[Category: Irie M]]
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[[Category: Matsuura, T.]]
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[[Category: Matsuura T]]
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[[Category: Glyoxalase]]
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[[Category: Lyase-lyase inhibitor complex]]
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Current revision

Human Glyoxalase I with an N-hydroxypyridone derivative inhibitor

PDB ID 3w0t

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