3w0u
From Proteopedia
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| - | {{STRUCTURE_3w0u| PDB=3w0u | SCENE= }} | ||
| - | ===human Glyoxalase I with an N-hydroxypyridone inhibitor=== | ||
| - | == | + | ==human Glyoxalase I with an N-hydroxypyridone inhibitor== |
| - | [[http://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN | + | <StructureSection load='3w0u' size='340' side='right'caption='[[3w0u]], [[Resolution|resolution]] 1.70Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3w0u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W0U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPW:N-[3-(1-HYDROXY-6-OXO-4-PHENYL-1,6-DIHYDRO-PYRIDIN-2-YL)-5-METHANESULFONYLAMINO-PHENYL]-METHANESULFONAMIDE'>HPW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w0u OCA], [https://pdbe.org/3w0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w0u RCSB], [https://www.ebi.ac.uk/pdbsum/3w0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w0u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LGUL_HUMAN LGUL_HUMAN] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B.<ref>PMID:19199007</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Glyoxalase 3D structures|Glyoxalase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Fukami | + | [[Category: Large Structures]] |
| - | [[Category: Irie | + | [[Category: Fukami TA]] |
| - | [[Category: Matsuura | + | [[Category: Irie M]] |
| - | + | [[Category: Matsuura T]] | |
| - | + | ||
Current revision
human Glyoxalase I with an N-hydroxypyridone inhibitor
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