4img

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{{STRUCTURE_4img| PDB=4img | SCENE= }}
 
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===Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164 mutant complexed with N-Glycolylneuraminic acid===
 
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{{ABSTRACT_PUBMED_24152047}}
 
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==Function==
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==Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164 mutant complexed with N-Glycolylneuraminic acid==
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[[http://www.uniprot.org/uniprot/NANA_PASMU NANA_PASMU]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).
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<StructureSection load='4img' size='340' side='right'caption='[[4img]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4img]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pasteurella_multocida_subsp._gallicida_P1059 Pasteurella multocida subsp. gallicida P1059]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IMG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ME2:1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE'>ME2</scene>, <scene name='pdbligand=NGF:3,5-DIDEOXY-5-[(HYDROXYACETYL)AMINO]-D-GLYCERO-D-GALACTO-NON-2-ULOSONIC+ACID'>NGF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4img FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4img OCA], [https://pdbe.org/4img PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4img RCSB], [https://www.ebi.ac.uk/pdbsum/4img PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4img ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NANA_PASMU NANA_PASMU] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity).
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==About this Structure==
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==See Also==
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[[4img]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pasteurella_multocida_subsp._gallicida_p1059 Pasteurella multocida subsp. gallicida p1059]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IMG OCA].
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*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024152047</ref><references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: N-acetylneuraminate lyase]]
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[[Category: Pasteurella multocida subsp. gallicida P1059]]
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[[Category: Pasteurella multocida subsp. gallicida p1059]]
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[[Category: Fisher AJ]]
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[[Category: Fisher, A J.]]
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[[Category: Huynh N]]
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[[Category: Huynh, N.]]
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[[Category: Lyase]]
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[[Category: Schiff base]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure of Pasteurella multocida N-Acetyl-D-Neuraminic acid lyase K164 mutant complexed with N-Glycolylneuraminic acid

PDB ID 4img

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