4l4y
From Proteopedia
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| - | {{STRUCTURE_4l4y| PDB=4l4y | SCENE= }} | ||
| - | ===Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition=== | ||
| - | {{ABSTRACT_PUBMED_24047255}} | ||
| - | == | + | ==Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition== |
| - | [[http://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI | + | <StructureSection load='4l4y' size='340' side='right'caption='[[4l4y]], [[Resolution|resolution]] 1.90Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4l4y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4y OCA], [https://pdbe.org/4l4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4y RCSB], [https://www.ebi.ac.uk/pdbsum/4l4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | [[Category: Escherichia coli | + | </StructureSection> |
| - | [[Category: | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Eo Y]] |
| - | [[Category: | + | [[Category: Ha JH]] |
| - | + | [[Category: Ryu KS]] | |
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Current revision
Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition
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