Ribosomal protein L19
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' scene='Ribosomal_protein_L19/Cv/1' caption='Ribosomal protein L19 (PDB code [[4v5k]])'> | |
| - | + | == Function == | |
| - | + | '''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L19/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits<ref>PMID:19799608</ref>. | |
| - | '''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L19/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits. | + | |
| - | + | ||
| - | + | ||
| + | == Relevance == | ||
| + | RPL19 is highly expressed in human breast tumors<ref>PMID:8095182</ref>. RPL19 is a prognostic marker for prostate cancer<ref>PMID:16609016</ref>. | ||
| + | </StructureSection> | ||
== 3D Structures of Ribosomal protein L19 == | == 3D Structures of Ribosomal protein L19 == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | ===L19 in 50S subunit+RNA=== | ||
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| - | [[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL19 in 50S subunit+RNA fragments-''Thermus thermophilus'' <br /> | ||
| - | [[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47 ]], [[2v49]], [[1vsa]], [[2hgj]], [[ 2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[2xtg]], [[2xux]], [[2xqe]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA]] <BR /> | ||
| - | [[3fin]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR /> | ||
| - | [[2wwq]] – EcRPL19 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<BR /> | ||
| - | [[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3oas]], [[3oat]], [[3ofd]], [[3og0]], [[3ofq]], [[1vt2]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA<BR /> | ||
| - | [[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR /> | ||
| - | [[3kcr]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<BR /> | ||
| - | [[3bbo]] - RPL19 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<BR /> | ||
| - | [[2zjq]], [[2zjr]], [[1nkw]] - DrRPL19 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<BR /> | ||
| - | [[1kqs]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA]] - ''Haloarcula marismortui''<BR /> | ||
| - | [[1jj2]], [[1ffk]], [[3cc2]], [[3cc4]], [[2otj]], [[2otl]], [[1s72]], [[1qvf]], [[1nji]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA<BR /> | ||
| - | [[1qvg]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA<BR /> | ||
| - | [[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA (mutant)<BR /> | ||
| - | [[3cma]], [[3cme]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-CAP-BIO | ||
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| - | ===L19 in 50S subunit + antibiotics=== | ||
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| - | [[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL19 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+antibiotic <BR /> | ||
| - | [[2qam]], [[2qao]], [[2qba]], [[2qbc]], [[2qoz]], [[2qp1]], [[3ofc]], [[3ofz]], [[3ofr]], [[3orb]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+antibiotic<BR /> | ||
| - | [[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] - TtRPL19 in 50S subunit+5S RRNA+23S RRNA+antibiotic<BR /> | ||
| - | [[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3cxc]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[3cd6]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+antibiotic<BR /> | ||
| - | [[1m90]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin<BR /> | ||
| - | [[3cpw]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+ linezolid+CCA-Phe-ACA | ||
| - | |||
| - | ===L19 in 50S subunit + ribosome releasing factor (RRF)=== | ||
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| - | [[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+RRF<BR /> | ||
| - | [[2rdo]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<BR /> | ||
| - | |||
| - | ===L19 in 50S subunit + various proteins=== | ||
| - | |||
| - | [[2vhm]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<BR /> | ||
| - | [[2j28]] - EcRPL19 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<BR /> | ||
| - | [[1w2b]] - HmRPL19P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal | ||
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| - | ===L19 in the 60S subunit=== | ||
| - | |||
| - | [[3o5h]], [[3o58]] - yRPL19 in 60S subunit+5S RRNA+25S RRNA+5.8S RRNA – yeast<BR /> | ||
| - | [[1s1i]] - yRPL19 in 60S subunit+5S RRNA+5.8S RRNA – Cryo EM<BR /> | ||
| - | [[3jyw]] – RPL19 in 60S subunit – Cryo EM – ''Thermomyces lanuginosus''<BR /> | ||
| - | [[2ftc]] - RPL19 in 60S subunit+16S RRNA – Cryo EM – bovine<BR /> | ||
| - | [[3izr]] – wRPL19 in the 60S subunit – wheat | ||
| - | |||
| - | ===L19 in large + small ribosomal subunit=== | ||
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| - | [[1ml5]] - EcRPL19 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<BR /> | ||
| - | |||
| - | ===L19 in the 80S ribosome=== | ||
| - | |||
| - | [[2zkr]] – dRPL19 in 80S ribosome – dog – Cryo EM<BR /> | ||
===L19 in part of 80S ribosome=== | ===L19 in part of 80S ribosome=== | ||
| - | [[2ww9]], [[2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – Cryo EM<BR /> | + | [[2ww9]], [[2wwa]] – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<BR /> |
| - | [[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – Cryo EM<BR /> | + | [[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<BR /> |
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Ribosomal protein L19
Updated on 22-October-2017
L19 in part of 80S ribosome
2ww9, 2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM
2wwb - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM
References
- ↑ Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, Yasuda M, Uramoto H, Hanagiri T, Yasumoto K. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. Cancer Sci. 2010 Jan;101(1):46-53. doi: 10.1111/j.1349-7006.2009.01351.x. Epub, 2009 Sep 9. PMID:19799608 doi:http://dx.doi.org/10.1111/j.1349-7006.2009.01351.x
- ↑ Henry JL, Coggin DL, King CR. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res. 1993 Mar 15;53(6):1403-8. PMID:8095182
- ↑ Bee A, Ke Y, Forootan S, Lin K, Beesley C, Forrest SE, Foster CS. Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2061-5. PMID:16609016 doi:http://dx.doi.org/10.1158/1078-0432.CCR-05-2445
