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Ribosomal protein L21

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[[Image:RPL21.png|left|200px|thumb|Crystal Structure of Ribosomal protein L21 ([[2xg0]], chain V)]]
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<StructureSection load='' size='350' side='right' scene='Ribosomal_protein_L21/Cv/1' caption='Ribosomal protein L21 (PDB code [[4v5k]])'>
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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE=Ribosomal_protein_L21/Cv/1 |right|CAPTION=Ribosomal protein L21 ([[2xg0]], chain V) }}
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== Function ==
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'''Ribosomal protein L21''' (RPL21) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L21/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL21 binds to 23S RRNA in the presence of RPL20<ref>PMID:22105802</ref>.
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'''Ribosomal protein L21''' (RPL21) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L21/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL21 binds to 23S RRNA in the presence of RPL20.
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== Disease ==
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Mutation in RPL21 underlie hereditary hypotrichosis simplex<ref>PMID:21412954</ref>.
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{{TOC limit|limit=2}}
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</StructureSection>
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== References ==
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== 3D Structures of Ribosomal protein L21 ==
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<references/>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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===L21 in 50S subunit+RNA===
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – TtRPL21 in 50S subunit+RNA fragments – ''Thermus thermophilus'' <br />
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47 ]], [[2v49]], [[1vsa]], [[2hgj]], [[ 2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[2xtg]], [[2xux]], [[2xqe]] - TtRPL21 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL21 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
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[[2wwq]] – EcRPL21 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3oas]], [[3oat]], [[3ofd]], [[3og0]], [[3ofq]], [[1vt2]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny ]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p86]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
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[[3kcr]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
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[[3bbo]] - RPL21 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL21 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+CCA – ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]], [[3cc2]], [[3cc4]], [[2otj]], [[2otl]], [[1s72]], [[1qvf]], [[1nji]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA<br />
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[[1qvg]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+CCA<br />
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[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA (mutant) <br />
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[[3cma]], [[3cme]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+CCA-Phe-CAP-BIO
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===L21 in 50S subunit + antibiotics===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - DrRPL21 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+antibiotic<br />
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[[2qam]], [[2qao]], [[2qba]], [[2qbc]], [[2qoz]], [[2qp1]], [[3ofc]], [[3ofz]], [[3ofr]], [[3orb]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] - TtRPL21 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3cxc]], [[3i55]], [[3i56]], [[3g4s]], [[3g6e]], [[3g71]], [[3cd6]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
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[[1m90]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin<br />
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[[3cpw]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+ linezolid+CCA-Phe-ACA
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===L21 in 50S subunit + ribosome releasing factor (RRF)===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+RRF<br />
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[[2rdo]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<BR />
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===L21 in 50S subunit + various proteins===
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[[2vhm]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
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[[2j28]] - EcRPL21 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<BR />
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[[1w2b]] - HmRPL21P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal
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===L21 in the 60S subunit===
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[[3o5h]], [[3o58]] - yRPL21 in 60S subunit+5S RRNA+25S RRNA+5.8S RRNA – yeast<br />
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[[3jyw]] – RPL21 in 60S subunit – Cryo EM –''Thermomyces lanuginosus''<br />
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[[3izr]] – wRPL21 in the 60S subunit – wheat
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===L21 in the 80S ribosome===
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[[2zkr]] – dRPL21 in 80S ribosome – dog – Cryo EM<BR />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L21 (PDB code 4v5k)

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References

  1. ↑ Yin T, Pan G, Liu H, Wu J, Li Y, Zhao Z, Fu T, Zhou Y. The chloroplast ribosomal protein L21 gene is essential for plastid development and embryogenesis in Arabidopsis. Planta. 2012 May;235(5):907-21. doi: 10.1007/s00425-011-1547-0. Epub 2011 Nov 22. PMID:22105802 doi:http://dx.doi.org/10.1007/s00425-011-1547-0
  2. ↑ Zhou C, Zang D, Jin Y, Wu H, Liu Z, Du J, Zhang J. Mutation in ribosomal protein L21 underlies hereditary hypotrichosis simplex. Hum Mutat. 2011 Jul;32(7):710-4. doi: 10.1002/humu.21503. Epub 2011 Apr 26. PMID:21412954 doi:10.1002/humu.21503

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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