Ribosomal protein L16

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:27, 1 October 2017) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1wki.png|left|200px|thumb|Crystal Structure of Ribosomal protein L16 [[1wki]]]]
+
<StructureSection load='1wki' size='350' side='right' scene='' caption='Ribosomal protein L16 (PDB code [[1wki]])'>
-
{{STRUCTURE_1wki| PDB=1wki | SIZE=300| S |right|CAPTION=Ribosomal protein L16 NMR structure [[1wki]] }}
+
-
'''Ribosomal protein L16''' (RPL16) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA and is located at the A site of the peptidyltransferase center.
+
== Function ==
-
 
+
'''Ribosomal protein L16''' (RPL16) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It binds to 23S RRNA and is located at the A site of the peptidyltransferase center<ref>PMID:15561149</ref>.
-
{{TOC limit|limit=2}}
+
 +
== Relevance ==
 +
Mutations in RPL16 confer reduced susceptibility to the antibiotic evernimicin<ref>PMID:10681347</ref>.
 +
</StructureSection>
== 3D Structures of Ribosomal protein L16 ==
== 3D Structures of Ribosomal protein L16 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
===RPL16===
+
*Ribosomal protein L16
-
 
+
-
[[1wki]] – TtRPL16 – ''Thermus thermophilus'' - NMR<BR />
+
-
 
+
-
===L16 in 50S subunit+RNA===
+
-
 
+
-
[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]], [[4byc]], [[4bye]] – TtRPL16 in 50S subunit+RNA fragments<br />
+
-
[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47 ]], [[2v49]], [[1vsa]], [[2hgj]], [[ 2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[2xtg]], [[2xux]], [[2xqe]], [[4btd]], [[4kfi]], [[4kfl]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]], [[4k0m]], [[4k0q]], [[4jux]], [[4ejb]], [[4ejc]], [[3v6x]], [[3v6w]], [[4b8g]], [[4b8i]], [[3zn9]], [[3zne]], [[4g5l]], [[4g5n]], [[4g5u]], [[4g5w]], [[3v23]], [[3v25]], [[3v27]], [[3v29]], [[3v2d]], [[3v2f]], [[4dha]], [[4dhc]], [[4abs]], [[3uz1]], [[3uz2]], [[3uz8]], [[3uz9]], [[3uzf]], [[3uzh]], [[3uzk]], [[3uzn]], [[3uye]], [[3uyg]], [[3tve]], [[3tvh]], [[3uxq]], [[3uxr]], [[3zvp]] - TtRPL16 in 50S subunit+5S RRNA+23S RRNA<br />
+
-
[[3fin]] - TtRPL16 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
+
-
[[2wwq]] – EcRPL16 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
+
-
[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3oas]], [[3oat]], [[3ofd]], [[3og0]], [[3ofq]], [[1vt2]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]], [[4kix]], [[4kiz]], [[4kj1]], [[4kj3]], [[4kj5]], [[4kj7]], [[4kj9]], [[4kjb]], [[3uos]], [[3sgf]], [[3r8s]], [[3r8t]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA<br />
+
-
[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]], [[3j37]], [[3j19]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3izu]], [[3izt]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<BR />
+
-
[[3kcr]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
+
-
[[3bbo]] - RPL16 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
+
-
[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL16 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
+
-
[[3iy9]] – RPL16 in 50S subunit – ''Leishmania taretolae''
+
-
 
+
-
===L16 in 50S subunit + antibiotics===
+
-
 
+
-
[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]], [[4io9]], [[4ioa]], [[4ioc]] - DrRPL16 in 50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+antibiotic<br />
+
-
[[2qam]], [[2qao]], [[2qba]], [[2qbc]], [[2qoz]], [[2qp1]], [[3ofc]], [[3ofz]], [[3ofr]], [[3orb]], [[4gar]], [[4gau]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
+
-
[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]], [[4l6l]], [[4l6j]] - TtRPL16 in 50S subunit+5S RRNA+23S RRNA+antibiotic<br />
+
-
 
+
-
===L16 in large + small ribosomal subunit===
+
-
 
+
-
[[1ml5]] - EcRPL16 in 50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – EM<BR />
+
-
 
+
-
===L16 in 50S subunit + ribosome releasing factor (RRF)===
+
-
 
+
-
[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+RRF<br />
+
-
[[2rdo]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<BR />
+
-
 
+
-
===L16 in 50S subunit + various proteins===
+
-
 
+
-
[[2vhm]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
+
-
[[2j28]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<BR />
+
-
[[3j01]] - EcRPL16 in 50S subunit+5S RRNA+23S RRNA+ preprotein translocase<br />
+
-
 
+
-
===L16 in the 60S subunit===
+
-
 
+
-
[[3o5h]], [[3o58]] - yRPL16 in 60S subunit+5S RRNA+25S RRNA+5.8S RRNA – yeast<br />
+
-
[[1s1i]] - yRPL16 in 60S subunit+5S RRNA+5.8S RRNA – Cryo EM<BR />
+
-
[[3u5e]], [[3u5i]] - yRPL16 in 60S subunit<br />
+
-
[[4b6a]] - yRPL16 in 60S subunit + P0 + P1 + P2 + ARX1 – Cryo EM<br />
+
-
[[3jyw]] – RPL16 in 60S subunit – Cryo EM – ''Thermomyces lanuginosus''<br />
+
-
[[2ftc]] - RPL16 in 60S subunit+16S RRNA – Cryo EM – bovine
+
-
===L16 in part of 50S subunit===
+
**[[1wki]] – TtRPL16 – ''Thermus thermophilus'' - NMR<BR />
 +
**[[4cug]] – RPL16 + RPL16 arginyl hydroxylase – ''Rhodothermus marinus''<br />
-
[[1njm]], [[1njp]] – DrRPL16 + 23S RRNA + tRNA acceptor stEM mimic + general stress protein CTC + antibiotic
+
*Ribosomal protein L16 in part of 50S subunit
 +
**[[1njm]], [[1njp]] – DrRPL16 + 23S RRNA + tRNA acceptor stEM mimic + general stress protein CTC + antibiotic - ''Deinococcus radiodurans''<br />
 +
**[[1y69]] - DrRPL16 + RPL27 + 23S RRNA +5S RRNA + ribosome recycling factor + ribosome releasing factor<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L16 (PDB code 1wki)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L16

Updated on 01-October-2017

References

  1. ↑ Nishimura M, Yoshida T, Shirouzu M, Terada T, Kuramitsu S, Yokoyama S, Ohkubo T, Kobayashi Y. Solution structure of ribosomal protein L16 from Thermus thermophilus HB8. J Mol Biol. 2004 Dec 10;344(5):1369-83. PMID:15561149 doi:10.1016/j.jmb.2004.10.011
  2. ↑ Adrian PV, Zhao W, Black TA, Shaw KJ, Hare RS, Klugman KP. Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action. Antimicrob Agents Chemother. 2000 Mar;44(3):732-8. PMID:10681347

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Ribosomal_protein_L16"
Personal tools