3j0d

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{{STRUCTURE_3j0d| PDB=3j0d | SCENE= }}
 
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===Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex===
 
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{{ABSTRACT_PUBMED_22388519}}
 
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==Function==
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==Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex==
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[[http://www.uniprot.org/uniprot/RRF_THET8 RRF_THET8]] Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity). [[http://www.uniprot.org/uniprot/RL11_ECOLI RL11_ECOLI]] This protein binds directly to 23S ribosomal RNA. Forms the L11 stalk, which is mobile in the ribosome, indicating its contribution to the activity of initiation, elongation and release factors.[HAMAP-Rule:MF_00736_B] [[http://www.uniprot.org/uniprot/RS12_ECOLI RS12_ECOLI]] With S4 and S5 plays an important role in translational accuracy.[HAMAP-Rule:MF_00403_B] Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).[HAMAP-Rule:MF_00403_B] Cryo-EM studies suggest that S12 contacts the EF-Tu bound tRNA in the A-site during codon-recognition. This contact is most likely broken as the aminoacyl-tRNA moves into the peptidyl transferase center in the 50S subunit.[HAMAP-Rule:MF_00403_B]
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<SX load='3j0d' size='340' side='right' viewer='molstar' caption='[[3j0d]], [[Resolution|resolution]] 11.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3j0d]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J0D FirstGlance]. <br>
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[[3j0d]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J0D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j0d OCA], [https://pdbe.org/3j0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j0d RCSB], [https://www.ebi.ac.uk/pdbsum/3j0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j0d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL11_ECOLI RL11_ECOLI] This protein binds directly to 23S ribosomal RNA. Forms the L11 stalk, which is mobile in the ribosome, indicating its contribution to the activity of initiation, elongation and release factors.[HAMAP-Rule:MF_00736_B]
==See Also==
==See Also==
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*[[Ribosomal protein L11|Ribosomal protein L11]]
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*[[Ribosomal protein L11 3D structures|Ribosomal protein L11 3D structures]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
*[[Ribosomal protein S12|Ribosomal protein S12]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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==Reference==
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*[[Ribosome recycling factor|Ribosome recycling factor]]
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<ref group="xtra">PMID:022388519</ref><references group="xtra"/><references/>
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__TOC__
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</SX>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Thermus thermophilus]]
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[[Category: Large Structures]]
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[[Category: Agrawal, R K.]]
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[[Category: Agrawal RK]]
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[[Category: Iwakura, N.]]
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[[Category: Iwakura N]]
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[[Category: Kaji, A.]]
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[[Category: Kaji A]]
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[[Category: Kaji, H.]]
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[[Category: Kaji H]]
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[[Category: Shaikh, T R.]]
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[[Category: Shaikh TR]]
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[[Category: Yokoyama, T.]]
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[[Category: Yokoyama T]]
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[[Category: Ribosome]]
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[[Category: Ribosome recycling factor]]
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[[Category: Translation]]
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Current revision

Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex

3j0d, resolution 11.10Å

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