2lwl

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{{STRUCTURE_2lwl| PDB=2lwl | SCENE= }}
 
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===Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles===
 
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{{ABSTRACT_PUBMED_23938203}}
 
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==About this Structure==
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==Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles==
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[[2lwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWL OCA].
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<StructureSection load='2lwl' size='340' side='right'caption='[[2lwl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LWL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lwl OCA], [https://pdbe.org/2lwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lwl RCSB], [https://www.ebi.ac.uk/pdbsum/2lwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lwl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/D106A_HUMAN D106A_HUMAN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human beta-defensins (hBDs) are believed to function as alarm molecules that stimulate the adaptive immune system when a threat is present. In addition to its antimicrobial activity, defensins present other activities such as chemoattraction of a range of different cell types to the sites of inflammation. We have solved the structure of the hBD6 by NMR spectroscopy that contains a conserved beta-defensin domain followed by an extended C-terminus. We use NMR to monitor the interaction of hBD6 with microvesicles shed by breast cancer cell lines and with peptides derived from the extracellular domain of CC chemokine receptor 2 (Nt-CCR2) possessing or not possessing sulfation on Tyr26 and Tyr28. The NMR-derived model of the hBD6/CCR2 complex reveals a contiguous binding surface on hBD6, which comprises amino acid residues of the alpha-helix and beta2-beta3 loop. The microvesicle binding surface partially overlaps with the chemokine receptor interface. NMR spin relaxation suggests that free hBD6 and the hBD6/CCR2 complex exhibit microsecond-to-millisecond conformational dynamics encompassing the CCR2 binding site, which might facilitate selection of the molecular configuration optimal for binding. These data offer new insights into the structure-function relation of the hBD6-CCR2 interaction, which is a promising target for the design of novel anticancer agents.
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==Reference==
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Structural Basis for the Interaction of Human beta-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles.,De Paula VS, Gomes NS, Lima LG, Miyamoto CA, Monteiro RQ, Almeida FC, Valente AP J Mol Biol. 2013 Aug 11. pii: S0022-2836(13)00504-4. doi:, 10.1016/j.jmb.2013.08.001. PMID:23938203<ref>PMID:23938203</ref>
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<ref group="xtra">PMID:023938203</ref><references group="xtra"/><references/>
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[[Category: Human]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Almeida, F C.L.]]
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</div>
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[[Category: Gomes, N S.F.]]
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<div class="pdbe-citations 2lwl" style="background-color:#fffaf0;"></div>
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[[Category: Lima, L G.]]
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[[Category: Miyamoto, C A.]]
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==See Also==
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[[Category: Monteiro, R Q.]]
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*[[Defensin 3D structures|Defensin 3D structures]]
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[[Category: Paula, V S.de.]]
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== References ==
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[[Category: Valente, A.]]
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<references/>
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[[Category: Antimicrobial protein]]
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__TOC__
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[[Category: Breast cancer]]
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</StructureSection>
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[[Category: Dynamic]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Almeida FCL]]
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[[Category: Gomes NSF]]
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[[Category: Lima LG]]
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[[Category: Miyamoto CA]]
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[[Category: Monteiro RQ]]
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[[Category: Valente A]]
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[[Category: De Paula VS]]

Current revision

Structural Basis for the Interaction of Human β-Defensin 6 and Its Putative Chemokine Receptor CCR2 and Breast Cancer Microvesicles

PDB ID 2lwl

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