4ldc
From Proteopedia
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| - | {{STRUCTURE_4ldc| PDB=4ldc | SCENE= }} | ||
| - | ===Crystal Structure of DOC2B C2B domain=== | ||
| - | {{ABSTRACT_PUBMED_23994332}} | ||
| - | == | + | ==Crystal Structure of DOC2B C2B domain== |
| - | [[http://www.uniprot.org/uniprot/DOC2B_RAT DOC2B_RAT | + | <StructureSection load='4ldc' size='340' side='right'caption='[[4ldc]], [[Resolution|resolution]] 1.26Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[4ldc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LDC FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.264Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ldc OCA], [https://pdbe.org/4ldc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ldc RCSB], [https://www.ebi.ac.uk/pdbsum/4ldc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ldc ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/DOC2B_RAT DOC2B_RAT] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.<ref>PMID:18596155</ref> <ref>PMID:20150444</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Almagor L]] | ||
| + | [[Category: Giladi M]] | ||
| + | [[Category: Hirsch JA]] | ||
Current revision
Crystal Structure of DOC2B C2B domain
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