4ndw

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(New page: '''Unreleased structure''' The entry 4ndw is ON HOLD Authors: Gangwar, S.P., Meena, S.R., Saxena, A.K. Description: Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTE...)
Current revision (08:56, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4ndw is ON HOLD
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==Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)==
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<StructureSection load='4ndw' size='340' side='right'caption='[[4ndw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Gangwar, S.P., Meena, S.R., Saxena, A.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ndw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NDW FirstGlance]. <br>
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Description: Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ndw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ndw OCA], [https://pdbe.org/4ndw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ndw RCSB], [https://www.ebi.ac.uk/pdbsum/4ndw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ndw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ESPR_MYCTU ESPR_MYCTU] Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression.<ref>PMID:18685700</ref> <ref>PMID:22389481</ref> <ref>PMID:22479184</ref> <ref>PMID:21883526</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Gangwar SP]]
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[[Category: Meena SR]]
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[[Category: Saxena AK]]

Current revision

Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR)

PDB ID 4ndw

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