4nft
From Proteopedia
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(New page: '''Unreleased structure''' The entry 4nft is ON HOLD Authors: Shan, S., Pan, L., Mao, Z., Wang, W., Sun, J., Dong, Q., Liang, X., Ding, X., Chen, S., Dai, L., Zhang, Z., Zhu, B., Zhou, ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human lnkH2B-h2A.Z-Anp32e== | |
| + | <StructureSection load='4nft' size='340' side='right'caption='[[4nft]], [[Resolution|resolution]] 2.61Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4nft]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NFT FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nft OCA], [https://pdbe.org/4nft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nft RCSB], [https://www.ebi.ac.uk/pdbsum/4nft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nft ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H2AZ_HUMAN H2AZ_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.<ref>PMID:15878876</ref> [https://www.uniprot.org/uniprot/H2B2E_HUMAN H2B2E_HUMAN] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Dai L]] | ||
| + | [[Category: Ding X]] | ||
| + | [[Category: Dong Q]] | ||
| + | [[Category: Liang X]] | ||
| + | [[Category: Mao Z]] | ||
| + | [[Category: Pan L]] | ||
| + | [[Category: Shan S]] | ||
| + | [[Category: Sun J]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Zhang Z]] | ||
| + | [[Category: Zhou Z]] | ||
| + | [[Category: Zhu B]] | ||
Current revision
Crystal structure of human lnkH2B-h2A.Z-Anp32e
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