4m2s

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{{STRUCTURE_4m2s| PDB=4m2s | SCENE= }}
 
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===Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR===
 
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{{ABSTRACT_PUBMED_24155053}}
 
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==Function==
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==Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR==
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[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
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<StructureSection load='4m2s' size='340' side='right'caption='[[4m2s]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4m2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M2S FirstGlance]. <br>
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[[4m2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2S OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JZ:(4R,11R,18R)-4,11,18-TRI(PROPAN-2-YL)-6,13,20-TRISELENA-3,10,17,22,23,24-HEXAAZATETRACYCLO[17.2.1.1~5,8~.1~12,15~]TETRACOSA-1(21),5(24),7,12(23),14,19(22)-HEXAENE-2,9,16-TRIONE'>0JZ</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m2s OCA], [https://pdbe.org/4m2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m2s RCSB], [https://www.ebi.ac.uk/pdbsum/4m2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m2s ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024155053</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Xenobiotic-transporting ATPase]]
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[[Category: Aller SG]]
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[[Category: Aller, S G.]]
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[[Category: Jaimes KF]]
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[[Category: Jaimes, K F.]]
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[[Category: Li J]]
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[[Category: Li, J.]]
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[[Category: Adenosine triphosphate]]
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[[Category: Atp-binding cassette transporter]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Multidrug efflux]]
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Current revision

Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR

PDB ID 4m2s

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