2q3h

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[[Image:2q3h.jpg|left|200px]]<br /><applet load="2q3h" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q3h, resolution 1.73&Aring;" />
 
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'''The crystal structure of RhouA in the GDP-bound state.'''<br />
 
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==About this Structure==
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==The crystal structure of RhouA in the GDP-bound state.==
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2Q3H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GDP:'>GDP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3H OCA].
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<StructureSection load='2q3h' size='340' side='right'caption='[[2q3h]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3h OCA], [https://pdbe.org/2q3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3h RCSB], [https://www.ebi.ac.uk/pdbsum/2q3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHOU_HUMAN RHOU_HUMAN] Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.<ref>PMID:11459829</ref> <ref>PMID:16472646</ref> <ref>PMID:17620058</ref> <ref>PMID:18086875</ref> <ref>PMID:21834987</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3h ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von.]]
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[[Category: Doyle DA]]
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[[Category: Doyle, D A.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Savitsky P]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P.]]
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[[Category: Ugochukwu E]]
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[[Category: Sundstrom, M.]]
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[[Category: Umeano C]]
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[[Category: Ugochukwu, E.]]
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[[Category: Uppenberg J]]
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[[Category: Umeano, C.]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J.]]
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[[Category: Yang X]]
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[[Category: Weigelt, J.]]
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[[Category: Zhao Y]]
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[[Category: Yang, X.]]
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[[Category: Von Delft F]]
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[[Category: Zhao, Y.]]
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[[Category: GDP]]
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[[Category: MG]]
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[[Category: gtpase]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:35:31 2008''
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Current revision

The crystal structure of RhouA in the GDP-bound state.

PDB ID 2q3h

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OCA

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