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2q5e

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[[Image:2q5e.jpg|left|200px]]<br /><applet load="2q5e" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q5e, resolution 2.510&Aring;" />
 
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'''Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2'''<br />
 
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==About this Structure==
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==Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2==
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2Q5E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA].
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<StructureSection load='2q5e' size='340' side='right'caption='[[2q5e]], [[Resolution|resolution]] 2.51&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Phosphoprotein phosphatase]]
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<table><tr><td colspan='2'>[[2q5e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q5E FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.51&#8491;</td></tr>
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[[Category: Almo, S C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Bain, K T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q5e OCA], [https://pdbe.org/2q5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q5e RCSB], [https://www.ebi.ac.uk/pdbsum/2q5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q5e ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2q5e TOPSAN]</span></td></tr>
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[[Category: Bonanno, J B.]]
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</table>
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[[Category: Burley, S K.]]
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== Function ==
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[[Category: Dickey, M.]]
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[https://www.uniprot.org/uniprot/CTDS2_HUMAN CTDS2_HUMAN] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref>
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[[Category: Lau, C.]]
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== Evolutionary Conservation ==
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Romero, R.]]
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Check<jmol>
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[[Category: Sauder, J M.]]
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<jmolCheckbox>
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[[Category: Smith, D.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q5/2q5e_consurf.spt"</scriptWhenChecked>
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[[Category: Wasserman, S.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: MG]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: hydrolase]]
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</jmolCheckbox>
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[[Category: new york structural genomix research consortium]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q5e ConSurf].
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[[Category: nysgxrc]]
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<div style="clear:both"></div>
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[[Category: protein structure initiative]]
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[[Category: psi-2]]
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[[Category: structural genomics]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:36:11 2008''
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Almo SC]]
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[[Category: Bain KT]]
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[[Category: Bonanno JB]]
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[[Category: Burley SK]]
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[[Category: Dickey M]]
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[[Category: Lau C]]
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[[Category: Romero R]]
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[[Category: Sauder JM]]
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[[Category: Smith D]]
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[[Category: Wasserman S]]

Current revision

Crystal structure of human carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

PDB ID 2q5e

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