4my8
From Proteopedia
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| - | {{STRUCTURE_4my8| PDB=4my8 | SCENE= }} | ||
| - | ===Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor Q21=== | ||
| - | == | + | ==Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor Q21== |
| - | [[http://www.uniprot.org/uniprot/ | + | <StructureSection load='4my8' size='340' side='right'caption='[[4my8]], [[Resolution|resolution]] 2.29Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4my8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MY8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2924Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=Q21:(2S)-2-(NAPHTHALEN-1-YLOXY)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]PROPANAMIDE'>Q21</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4my8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my8 OCA], [https://pdbe.org/4my8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4my8 RCSB], [https://www.ebi.ac.uk/pdbsum/4my8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4my8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A6L8P2U9_BACAN A0A6L8P2U9_BACAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]] |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bacillus anthracis str. Ames]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Cuny | + | [[Category: Anderson WF]] |
| - | [[Category: Gorla | + | [[Category: CSGID]] |
| - | [[Category: Gu | + | [[Category: Cuny G]] |
| - | [[Category: Hedstrom | + | [[Category: Gorla SK]] |
| - | [[Category: Joachimiak | + | [[Category: Gu M]] |
| - | [[Category: Kavitha | + | [[Category: Hedstrom L]] |
| - | [[Category: Kim | + | [[Category: Joachimiak A]] |
| - | [[Category: Makowska-Grzyska | + | [[Category: Kavitha M]] |
| - | + | [[Category: Kim Y]] | |
| - | + | [[Category: Makowska-Grzyska M]] | |
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Current revision
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor Q21
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