Ribosomal protein L23

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[[Image:1n88.png|left|200px|thumb|Crystal Structure of Ribosomal protein L23 ([[1n88]])]]
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<StructureSection load='1n88' size='350' side='right' scene='' caption='Ribosomal protein L23 NMR structure (PDB code [[1n88]])'>
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{{STRUCTURE_1n88| PDB=1n88 | SIZE=300| SCENE=Ribosomal_protein_L23/Cv/1 |right|CAPTION=Ribosomal protein L23 NMR structure ([[1n88]]) }}
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== Function ==
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'''Ribosomal protein L23''' (RPL23) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL23 binds to 23S or 26S RRNA<ref>PMID:15314173</ref>.
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'''Ribosomal protein L23''' (RPL23) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL23 binds to 23S or 26S RRNA.
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{{TOC limit|limit=2}}
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== Relevance ==
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RPL23 promotes multi drug resistance in gastric cancer cells<ref>PMID:15149863</ref>.
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</StructureSection>
== 3D Structures of Ribosomal protein L23 ==
== 3D Structures of Ribosomal protein L23 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===RPL23===
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*Ribosomal protein L23
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[[1n88]] – TtRPL23 – NMR - ''Thermus thermophilus''
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===L23 in 50S subunit+RNA===
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[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]], [[4byc]], [[4bye]] – TtRPL23 in 50S subunit+RNA fragments <br />
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[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[3hux]], [[3huz]], [[2wh2]], [[2wh4]], [[2wdi]], [[2wdj]], [[2wdl]], [[2wdn]], [[1vsp]], [[2v47 ]], [[2v49]], [[1vsa]], [[2hgj]], [[ 2hgq]], [[2hgu]], [[2j01]], [[2j03]], [[1yl3]], [[3mrz]], [[3ms1]], [[3i8f]], [[3i8i]], [[3i9c]], [[3i9e]], [[3f1f]], [[3f1h]], [[3d5b]], [[3d5d]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[2xtg]], [[2xux]], [[2xqe]],[[4btd]], [[4kfi]], [[4kfl]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]], [[4k0m]], [[4k0q]], [[4jux]], [[4ejb]], [[4ejc]], [[3v6x]], [[3v6w]], [[4b8g]], [[4b8i]], [[3zn9]], [[3zne]], [[4g5l]], [[4g5n]], [[4g5u]], [[4g5w]], [[3v23]], [[3v25]], [[3v27]], [[3v29]], [[3v2d]], [[3v2f]], [[4dha]], [[4dhc]], [[4abs]], [[3uz1]], [[3uz2]], [[3uz8]], [[3uz9]], [[3uzf]], [[3uzh]], [[3uzk]], [[3uzn]], [[3uye]], [[3uyg]], [[3tve]], [[3tvh]], [[3uxq]], [[3uxr]], [[3zvp]] - TtRPL23 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fin]] - TtRPL23 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[2wwq]] – EcRPL23 in 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA – ''Escherichia coli''<br />
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[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3oas]], [[3oat]], [[3ofd]], [[3og0]], [[3ofq]], [[1vt2]], [[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]], [[3j4x]], [[3j50]], [[3j51]], [[3j52]], [[3j54]], [[3j56]], [[3j58]], [[3j5a]], [[3j5c]], [[3j5e]], [[3j5g]], [[3j5i]], [[3j5k]], [[4kix]], [[4kiz]], [[4kj1]], [[4kj3]], [[4kj5]], [[4kj7]], [[4kj9]], [[4kjb]], [[3uos]], [[3sgf]], [[3r8s]], [[3r8t]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA<br />
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[[3fik]], [[2gya]], [[2gyc]], [[3bbx]], [[1p85]], [[1p86]], [[3j37]], [[3j19]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3izu]], [[3izt]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
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[[3bbo]] - RPL23 in 50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM – spinach<br />
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[[2zjq]], [[2zjr]], [[1nkw]] - DrRPL23 in 50S subunit+5S RRNA+23S RRNA – ''Deinococcus radiodurans''<br />
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[[1kqs]] - HmRPL23P in 50S subunit+5S RRNA+23S RRNA+CCA - ''Haloarcula marismortui''<br />
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[[1jj2]], [[1ffk]] - HmRPL23P in 50S subunit+5S RRNA+23S RRNA<br />
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[[3j3w]], [[3j3v]] – RPL23 in 50S subunit+ 23S RRNA – ''Bacillus subtilis'' – Cryo EM<br />
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===L23 in 50S subunit + antibiotics===
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[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]], [[4io9]], [[4ioa]], [[4ioc]] - DrRPL23 in 50S subunit+5S RRNA+23S RRNA+antibiotics<br />
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[[2qam]], [[2qao]], [[2qba]], [[2qbc]], [[2qoz]], [[2qp1]], [[3ofc]], [[3ofz]], [[3ofr]], [[3orb]], [[4gar]], [[4gau]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA+antibiotics<br />
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[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]], [[4l6l]], [[4l6j]] - TtRPL23 in 50S subunit+5S RRNA+23S RRNA+antibiotics<br />
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[[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3cxc]] - HmRPL23P in 50S subunit+5S RRNA+23S RRNA+antibiotics<br />
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[[1m90]] - HmRPL23P in 50S subunit+5S RRNA+23S RRNA+ sparsomycin+CCA-Phe-caproic acid-biotin
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===L23 in 50S subunit + ribosome releasing factor (RRF)===
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[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA+RRF<br />
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[[2rdo]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM
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===L23 in large subunit + various proteins===
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[[2vhm]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
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[[2j28]] - EcRPL23 in 50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<br />
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[[3j01]], [[3kcr]] – EcRPL23 in 50S subunit+5S RRNA+23S RRNA+ preprotein translocase<br />
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[[2vrh]] – EcRPL23 + RPL24 + RPL29 + trigger factor<br />
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[[2d3o]] - EcRPL23 + RPL24 + RPL29 + 23S RRNA + trigger factor<br />
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[[2aar]] - DrRPL23 + RPL29 + 23S RRNA + trigger factor<br />
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[[1w2b]] - HmRPL23P in 50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal<br />
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[[2x7n]] – yRPL23 + RPL24 + sarcin-ricin loop + translation initation factor 6 – yeast<br />
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[[2j37]], [[2go5]] – wRPL23 + RPL31 + RPL35 + RNA + signal recognition particle – wheat- EM
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===L23 in the 60S subunit===
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[[3o5h]], [[3o58]] - yRPL23 in 60S subunit+5S RRNA+25S RRNA+5.8S RRNA<br />
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[[1s1i]] - yRPL23 in 60S subunit+5S RRNA+5.8S RRNA – Cryo EM<br />
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[[3jyw]] – RPL23 in 60S subunit – Cryo EM – ''Thermomyces lanuginosus''<br />
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[[3izr]] – wRPL23 in the 60S subunit <br />
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[[4a17]], [[4a1e]], [[4a1a]], [[4a1c]] - RPL23 in 60S subunit+ 26S RRNA + EIF-6 – ''Tetrahymena thermophila''<br />
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[[3j39]] - RPL23 in 60S subunit+ P0 – ''Drosophila melanogaster'' – Cryo EM<br />
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[[3j3b] - RPL23 in 60S subunit+ P0 – human – Cryo EM<br />
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===L23 in large + small ribosomal subunit===
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[[1ml5]] - EcRPL23 in 50S ribosomal subunit+30S ribosomal<br /> subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA<br /> fragment+23S RRNA+5S RRNA+16S RRNA – EM
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===L23 in the 80S ribosome===
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**[[1n88]] – TtRPL23 – NMR - ''Thermus thermophilus''<br />
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**[[6fu8]] – EcRPL23 - ''Escherichia coli'' – Cryo EM<br />
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[[2zkr]] – dRPL23 in 80S ribosome – dog – Cryo EM
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*L23 in part of 50S ribosome
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===L23 in part of 80S ribosome===
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**[[2aar]] – DrRPL23 + RPL29 + 23S RRNA + trigger factor N terminal – ''Deinococcus radiodurans''<br />
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**[[2d3o]] – DrRPL23 + RPL24 + RPL29 + 23S RRNA + trigger factor N terminal <br />
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**[[2vrh]] – EcRPL23 + RPL24 + RPL29 + trigger factor – Cryo EM<br />
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[[2ww9]], [[2wwa]] – yRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – Cryo EM<br />
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*Ribosomal protein L23 in part of 80S ribosome
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[[2wwb]] - wRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – Cryo EM<br />
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[[2j37]] - wRPL23+RPL35+RPL31 + signal recognition particle + SRP RNA Cryo EM<br />
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===L23 in part of 60S ribosome===
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**[[2ww9]], [[2wwa]] – yRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<br />
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**[[2x7n]] - yRPL23+RPL24 + sarcin-ricin loop + EIF-6 - Cryo EM<br />
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**[[2wwb]] - wRPL23+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<br />
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**[[2j37]] - wRPL23+RPL35+RPL31 + signal recognition particle + SRP RNA Cryo EM<br />
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[[3j46]], [[3j45]] - EcRPL23+RPL1+RPL24+RPL29+23S RRNA+ SECE + SECG + SECY + NC100 + A-tRNA + P-tRNA – Cryo EM<br />
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*Ribosomal protein L23 in part of 60S ribosome
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**[[3j46]], [[3j45]] - EcRPL23+RPL1+RPL24+RPL29+23S RRNA+ SECE + SECG + SECY + NC100 + A-tRNA + P-tRNA - Cryo EM<br />
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Ribosomal protein L23 NMR structure (PDB code 1n88)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L23

Updated on 29-December-2019

References

  1. ↑ Dai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004 Sep;24(17):7654-68. PMID:15314173 doi:http://dx.doi.org/10.1128/MCB.24.17.7654-7668.2004
  2. ↑ Shi Y, Zhai H, Wang X, Han Z, Liu C, Lan M, Du J, Guo C, Zhang Y, Wu K, Fan D. Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Exp Cell Res. 2004 Jun 10;296(2):337-46. PMID:15149863 doi:http://dx.doi.org/10.1016/j.yexcr.2004.02.009

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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