2q62

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[[Image:2q62.jpg|left|200px]]<br /><applet load="2q62" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q62, resolution 1.800&Aring;" />
 
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'''Crystal Structure of ArsH from Sinorhizobium meliloti'''<br />
 
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==Overview==
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==Crystal Structure of ArsH from Sinorhizobium meliloti==
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Purified ArsH from Sinorhizobium meliloti exhibits NADPH:FMN-dependent reduction of molecular O2 to hydrogen peroxide and catalyzes reduction of azo dyes. The structure of ArsH was determined at 1.8A resolution. ArsH crystallizes with eight molecules in the asymmetric unit forming two tetramers. Each monomer has a core domain with a central five-stranded parallel beta-sheet and two monomers interact to form a classical flavodoxin-like dimer. The N- and C-terminal extensions of ArsH are involved in interactions between subunits and tetramer formation. The structure may provide insight in how ArsH participates in arsenic detoxification.
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<StructureSection load='2q62' size='340' side='right'caption='[[2q62]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2q62]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q62 FirstGlance]. <br>
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2Q62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sinorhizobium_meliloti Sinorhizobium meliloti] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q62 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q62 OCA], [https://pdbe.org/2q62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q62 RCSB], [https://www.ebi.ac.uk/pdbsum/2q62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q62 ProSAT]</span></td></tr>
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Crystal structure of the flavoprotein ArsH from Sinorhizobium meliloti., Ye J, Yang HC, Rosen BP, Bhattacharjee H, FEBS Lett. 2007 Aug 21;581(21):3996-4000. Epub 2007 Jul 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17673204 17673204]
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</table>
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[[Category: Single protein]]
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== Function ==
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[https://www.uniprot.org/uniprot/ARREH_RHIME ARREH_RHIME] Has NADPH-dependent FMN reductase activity. No activity with NADH. May play a role in resistance to heavy metal toxicity.<ref>PMID:17673204</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q6/2q62_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q62 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sinorhizobium meliloti]]
[[Category: Sinorhizobium meliloti]]
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[[Category: Bhattacharjee, H.]]
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[[Category: Bhattacharjee H]]
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[[Category: Rosen, B P.]]
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[[Category: Rosen BP]]
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[[Category: Yang, H.]]
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[[Category: Yang H]]
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[[Category: Ye, J.]]
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[[Category: Ye J]]
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[[Category: SO4]]
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[[Category: alpha/beta]]
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[[Category: flavoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:36:23 2008''
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Current revision

Crystal Structure of ArsH from Sinorhizobium meliloti

PDB ID 2q62

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