Ribosomal protein P2

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<StructureSection load='2jdl' size='350' side='right' caption='Structure of human ribosomal protein P2 complex with the ribosome inactivating proteintrichosanthin (PDB entry [[2jdl]])' scene=''>
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<StructureSection load='4v88' size='350' side='right' caption='Structure of Ribosomal protein P2 beta (PDB entry [[4v88]])' scene='56/568929/Cv/1'>
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== Function ==
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'''Ribosomal protein P2''' (RPLP2) is one of the 3 phosphoproteins in the large 60S subunit of the eukaryotic ribosome. RPLP2 plays an important role in the elongation step of protein synthesis<ref>PMID:1524426</ref>. RPLP2 makes a heterodimer with dimers of RPLP1.
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'''Ribosomal protein P2''' (RPLP2) is one of the 3 phosphoproteins in the large 60S subunit of the eukaryotic ribosome. RPLP2 plays an important role in the elongation step of protein synthesis. RPLP2 makes a heterodimer with dimers of RPLP1.
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== Relevance ==
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Antisense RPLP2 technology has potential to slow growth of cancer cells<ref>PMID:14981896</ref>.
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==P2 in the 60S subunit==
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== 3D Structures of ribosomal protein P2==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[2jdl]] - hRPLP2 peptide + ribosome inactivating protein trichosanthin – human<br />
[[2jdl]] - hRPLP2 peptide + ribosome inactivating protein trichosanthin – human<br />
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[[2w1o]] – hRPLP2 dimerization domain – NMR<br />
[[2w1o]] – hRPLP2 dimerization domain – NMR<br />
[[4beh]] – hRPLP2 + RPLP1 – NMR<br />
[[4beh]] – hRPLP2 + RPLP1 – NMR<br />
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[[3izs]] – yRPLP2 in 60S subunit + P0 + P1 – yeast - Cryo EM<br />
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[[4b6a]] – yRPLP2 in 60S subunit + P0 + P1 + ARX1 - Cryo EM<br />
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== References ==
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[[3j3b]] – hRPLP2 in 60S subunit + P0 + P1 - Cryo EM<br />
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<references/>
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[[Category: Topic Page]]

Current revision

Structure of Ribosomal protein P2 beta (PDB entry 4v88)

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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