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2q6m
From Proteopedia
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| - | [[Image:2q6m.jpg|left|200px]]<br /><applet load="2q6m" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2q6m, resolution 1.250Å" /> | ||
| - | '''Identification, Characterization and Structure of Cholix toxin from Vibrio cholerae'''<br /> | ||
| - | == | + | ==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with the PJ34 inhibitor== |
| - | + | <StructureSection load='2q6m' size='340' side='right'caption='[[2q6m]], [[Resolution|resolution]] 1.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2q6m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q6M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q6M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> | |
| - | [ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P34:N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE'>P34</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q6m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q6m OCA], [https://pdbe.org/2q6m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q6m RCSB], [https://www.ebi.ac.uk/pdbsum/2q6m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q6m ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | |
| - | + | ==See Also== | |
| + | *[[Exotoxin 3D structures|Exotoxin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae]] | ||
| + | [[Category: Jorgensen R]] | ||
| + | [[Category: Merrill AR]] | ||
Current revision
Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with the PJ34 inhibitor
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