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2q7f

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[[Image:2q7f.jpg|left|200px]]<br /><applet load="2q7f" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q7f, resolution 2.49&Aring;" />
 
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'''Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site'''<br />
 
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==Overview==
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==Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site==
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YrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.
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<StructureSection load='2q7f' size='340' side='right'caption='[[2q7f]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2q7f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7F FirstGlance]. <br>
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2Q7F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7F OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7f OCA], [https://pdbe.org/2q7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7f RCSB], [https://www.ebi.ac.uk/pdbsum/2q7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7f ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site., Han D, Oh J, Kim K, Lim H, Kim Y, Biochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17624311 17624311]
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== Function ==
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[https://www.uniprot.org/uniprot/YRRB_BACSU YRRB_BACSU] Could be an interacting mediator in the complex formation among RNA sulfuration components, RNA processing components, and aminoacyl-tRNA synthetases.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7f ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Han, D.]]
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[[Category: Han D]]
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[[Category: Kim, K.]]
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[[Category: Kim K]]
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[[Category: Lim, H.]]
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[[Category: Lim H]]
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[[Category: Oh, J.]]
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[[Category: Oh J]]
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[[Category: protein binding]]
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[[Category: tpr]]
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[[Category: yrrb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:36:50 2008''
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Current revision

Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site

PDB ID 2q7f

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