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3qlx

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{{STRUCTURE_3qlx| PDB=3qlx | SCENE= }}
 
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===Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)===
 
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{{ABSTRACT_PUBMED_21726415}}
 
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==About this Structure==
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==Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)==
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[[3qlx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLX OCA].
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<StructureSection load='3qlx' size='340' side='right'caption='[[3qlx]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qlx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.239&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=QLR:6-METHYL-5-[(3R)-3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>QLR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlx OCA], [https://pdbe.org/3qlx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlx RCSB], [https://www.ebi.ac.uk/pdbsum/3qlx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]
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==Reference==
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==See Also==
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<ref group="xtra">PMID:021726415</ref><references group="xtra"/><references/>
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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[[Category: Atcc 2001]]
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__TOC__
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[[Category: Anderson, A C.]]
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</StructureSection>
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[[Category: Bendel, S D.]]
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[[Category: Large Structures]]
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[[Category: Paulsen, J L.]]
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[[Category: Anderson AC]]
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[[Category: Antifungal agent]]
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[[Category: Bendel SD]]
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[[Category: Candida glabrata]]
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[[Category: Paulsen JL]]
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[[Category: Drug design]]
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[[Category: Enzyme inhibitor]]
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[[Category: Fungal protein]]
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[[Category: Model]]
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[[Category: Molecular structure]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Structure-activity relationship]]
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[[Category: Tetrahydrofolate dehydrogenase]]
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Current revision

Candida glabrata dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)

PDB ID 3qlx

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