2anq

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{{STRUCTURE_2anq| PDB=2anq | SCENE= }}
 
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===Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.===
 
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{{ABSTRACT_PUBMED_17125251}}
 
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==Function==
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==Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<StructureSection load='2anq' size='340' side='right'caption='[[2anq]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2anq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANQ FirstGlance]. <br>
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[[2anq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANQ OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1A:(2,5-DIMETHYLBENZENE-1,4-DIYL)DIMETHANEDIYL+BIS(N-CARBAMIMIDOYLCARBAMIMIDOTHIOATE)'>C1A</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2anq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2anq OCA], [https://pdbe.org/2anq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2anq RCSB], [https://www.ebi.ac.uk/pdbsum/2anq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2anq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2anq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2anq ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017125251</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
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[[Category: Dihydrofolate reductase]]
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[[Category: Brown ED]]
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[[Category: Brown, E D.]]
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[[Category: Daigle DM]]
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[[Category: Daigle, D M.]]
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[[Category: Hughes DW]]
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[[Category: Hughes, D W.]]
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[[Category: Jackson SG]]
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[[Category: Jackson, S G.]]
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[[Category: Junop MS]]
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[[Category: Junop, M S.]]
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[[Category: Mayer S]]
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[[Category: Mayer, S.]]
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[[Category: Organ M]]
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[[Category: Organ, M.]]
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[[Category: Summerfield RL]]
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[[Category: Summerfield, R L.]]
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[[Category: Dhfr]]
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[[Category: Oxidoreductase]]
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[[Category: Protein inhibitor complex]]
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Current revision

Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a.

PDB ID 2anq

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