This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4lwb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (16:27, 20 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_4lwb| PDB=4lwb | SCENE= }}
 
-
===Structure of Bacillus subtilis nitric oxide synthase in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine===
 
-
{{ABSTRACT_PUBMED_24145412}}
 
-
==Function==
+
==Structure of Bacillus subtilis nitric oxide synthase in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine==
-
[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
+
<StructureSection load='4lwb' size='340' side='right'caption='[[4lwb]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4lwb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LWB FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=QJ8:6-({[(3R,5S)-5-{[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY]METHYL}PYRROLIDIN-3-YL]OXY}METHYL)-4-METHYLPYRIDIN-2-AMINE'>QJ8</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwb OCA], [https://pdbe.org/4lwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lwb RCSB], [https://www.ebi.ac.uk/pdbsum/4lwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lwb ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU] Catalyzes the production of nitric oxide.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Nitric oxide (NO) produced by bacterial NOS functions as a cytoprotective agent against oxidative stress in Staphylococcus aureus, Bacillus anthracis, and Bacillus subtilis. The screening of several NOS-selective inhibitors uncovered two inhibitors with potential antimicrobial properties. These two compounds impede the growth of B. subtilis under oxidative stress, and crystal structures show that each compound exhibits a unique binding mode. Both compounds serve as excellent leads for the future development of antimicrobials against bacterial NOS-containing bacteria.
-
==About this Structure==
+
Structural and biological studies on bacterial nitric oxide synthase inhibitors.,Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL Proc Natl Acad Sci U S A. 2013 Oct 21. PMID:24145412<ref>PMID:24145412</ref>
-
[[4lwb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWB OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<ref group="xtra">PMID:024145412</ref><references group="xtra"/><references/>
+
</div>
-
[[Category: Bacsu]]
+
<div class="pdbe-citations 4lwb" style="background-color:#fffaf0;"></div>
-
[[Category: Holden, J K.]]
+
 
-
[[Category: Li, H.]]
+
==See Also==
-
[[Category: Poulos, T L.]]
+
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
-
[[Category: Nitric oxide synthase]]
+
== References ==
-
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
 +
[[Category: Large Structures]]
 +
[[Category: Holden JK]]
 +
[[Category: Li H]]
 +
[[Category: Poulos TL]]

Current revision

Structure of Bacillus subtilis nitric oxide synthase in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine

PDB ID 4lwb

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lwb"
Personal tools