3qlr

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{{STRUCTURE_3qlr| PDB=3qlr | SCENE= }}
 
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===Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)===
 
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{{ABSTRACT_PUBMED_21726415}}
 
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==About this Structure==
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==Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)==
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[[3qlr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_11006_[[candida_stellatoidea]] Atcc 11006 [[candida stellatoidea]]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLR OCA].
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<StructureSection load='3qlr' size='340' side='right'caption='[[3qlr]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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==Reference==
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<table><tr><td colspan='2'>[[3qlr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLR FirstGlance]. <br>
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<ref group="xtra">PMID:021726415</ref><references group="xtra"/><references/>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.149&#8491;</td></tr>
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[[Category: Anderson, A C.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=QLR:6-METHYL-5-[(3R)-3-(3,4,5-TRIMETHOXYPHENYL)PENT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE'>QLR</scene></td></tr>
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[[Category: Bendel, S D.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlr OCA], [https://pdbe.org/3qlr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlr RCSB], [https://www.ebi.ac.uk/pdbsum/3qlr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlr ProSAT]</span></td></tr>
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[[Category: Paulsen, J L.]]
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</table>
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[[Category: Antifungal agent]]
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== Function ==
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[[Category: Candida albican]]
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[https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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[[Category: Drug design]]
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__TOC__
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[[Category: Enzyme inhibitor]]
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</StructureSection>
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[[Category: Fungal protein]]
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[[Category: Candida albicans]]
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[[Category: Model]]
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[[Category: Large Structures]]
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[[Category: Molecular structure]]
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[[Category: Anderson AC]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Bendel SD]]
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[[Category: Structure-activity relationship]]
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[[Category: Paulsen JL]]
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[[Category: Tetrahydrofolate dehydrogenase]]
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Current revision

Candida albicans dihydrofolate reductase complexed with NADPH and 6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)pent-1-yn-1-yl]pyrimidine-2,4-diamine (UCP112A)

PDB ID 3qlr

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