4n14
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Cdc20 and apcin complex== | |
| - | + | <StructureSection load='4n14' size='340' side='right'caption='[[4n14]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4n14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N14 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WR7:2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL+[(1R)-2,2,2-TRICHLORO-1-(PYRIMIDIN-2-YLAMINO)ETHYL]CARBAMATE'>WR7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n14 OCA], [https://pdbe.org/4n14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n14 RCSB], [https://www.ebi.ac.uk/pdbsum/4n14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n14 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Luo X]] | ||
| + | [[Category: Tian W]] | ||
| + | [[Category: Yu H]] | ||
Current revision
Crystal structure of Cdc20 and apcin complex
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Categories: Homo sapiens | Large Structures | Luo X | Tian W | Yu H
