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2qcz

From Proteopedia

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[[Image:2qcz.jpg|left|200px]]<br /><applet load="2qcz" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qcz, resolution 2.700&Aring;" />
 
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'''Structure of N-terminal domain of E. Coli YaeT'''<br />
 
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==Overview==
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==Structure of N-terminal domain of E. Coli YaeT==
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Integral beta-barrel proteins are found in the outer membranes of mitochondria, chloroplasts, and Gram-negative bacteria. The machine that assembles these proteins contains an integral membrane protein, called YaeT in Escherichia coli, which has one or more polypeptide transport-associated (POTRA) domains. The crystal structure of a periplasmic fragment of YaeT reveals the POTRA domain fold and suggests a model for how POTRA domains can bind different peptide sequences, as required for a machine that handles numerous beta-barrel protein precursors. Analysis of POTRA domain deletions shows which are essential and provides a view of the spatial organization of this assembly machine.
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<StructureSection load='2qcz' size='340' side='right'caption='[[2qcz]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qcz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QCZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qcz OCA], [https://pdbe.org/2qcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qcz RCSB], [https://www.ebi.ac.uk/pdbsum/2qcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qcz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BAMA_ECOLI BAMA_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.<ref>PMID:15951436</ref> <ref>PMID:16102012</ref> <ref>PMID:16824102</ref> <ref>PMID:20378773</ref> <ref>PMID:21823654</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/2qcz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qcz ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2QCZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCZ OCA].
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*[[Bam complex 3D structures|Bam complex 3D structures]]
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== References ==
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==Reference==
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<references/>
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Structure and function of an essential component of the outer membrane protein assembly machine., Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D, Science. 2007 Aug 17;317(5840):961-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17702946 17702946]
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Escherichia coli K-12]]
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[[Category: Harrison, S C.]]
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[[Category: Large Structures]]
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[[Category: Kahne, D.]]
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[[Category: Harrison SC]]
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[[Category: Kim, S.]]
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[[Category: Kahne D]]
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[[Category: Malinverni, J C.]]
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[[Category: Kim S]]
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[[Category: Silhavy, T J.]]
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[[Category: Malinverni JC]]
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[[Category: Sliz, P.]]
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[[Category: Silhavy TJ]]
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[[Category: membrane protein]]
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[[Category: Sliz P]]
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[[Category: potra domain]]
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[[Category: protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:38:16 2008''
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Current revision

Structure of N-terminal domain of E. Coli YaeT

PDB ID 2qcz

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