4i0i

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{{STRUCTURE_4i0i| PDB=4i0i | SCENE= }}
 
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===SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors===
 
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==Function==
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==SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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<StructureSection load='4i0i' size='340' side='right'caption='[[4i0i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i0i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=957:N-[(1S,2R)-1-(3,5-DIFLUOROBENZYL)-3-({1-[4-(2,2-DIMETHYLPROPYL)THIOPHEN-2-YL]CYCLOPROPYL}AMINO)-2-HYDROXYPROPYL]ACETAMIDE'>957</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0i OCA], [https://pdbe.org/4i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0i RCSB], [https://www.ebi.ac.uk/pdbsum/4i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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==About this Structure==
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==See Also==
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[[4i0i]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0I OCA].
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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[[Category: Memapsin 2]]
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</StructureSection>
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[[Category: Brecht, E.]]
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[[Category: Homo sapiens]]
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[[Category: Yao, N.]]
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[[Category: Large Structures]]
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[[Category: Aspartic protease]]
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[[Category: Brecht E]]
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[[Category: Bace]]
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[[Category: Yao N]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Hydrolysis]]
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SPR and structural analysis yield insight towards mechanism of inhibition of BACE inhibitors

PDB ID 4i0i

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