4c8v

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{{STRUCTURE_4c8v| PDB=4c8v | SCENE= }}
 
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===Xenopus RSPO2 Fu1-Fu2 crystal form I===
 
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{{ABSTRACT_PUBMED_24225776}}
 
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==Function==
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==Xenopus RSPO2 Fu1-Fu2 crystal form I==
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[[http://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
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<StructureSection load='4c8v' size='340' side='right'caption='[[4c8v]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4c8v]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_tropicalis Xenopus tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C8V FirstGlance]. <br>
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[[4c8v]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_(silurana)_tropicalis Xenopus (silurana) tropicalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8V OCA].
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c8v OCA], [https://pdbe.org/4c8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c8v RCSB], [https://www.ebi.ac.uk/pdbsum/4c8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c8v ProSAT]</span></td></tr>
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</table>
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==Reference==
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== Function ==
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<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
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[[https://www.uniprot.org/uniprot/RSPO2_XENTR RSPO2_XENTR]] Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Activates neural markers and promotes muscle formation. Overexpression blocks activin, nodal and BMP4 signaling, suggesting that it may negatively regulate the TGF-beta pathway (By similarity).
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[[Category: Jones, E Y.]]
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__TOC__
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[[Category: Zebisch, M.]]
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</StructureSection>
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[[Category: Lgr4]]
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[[Category: Large Structures]]
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[[Category: Lgr5]]
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[[Category: Xenopus tropicalis]]
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[[Category: Lgr6]]
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[[Category: Jones EY]]
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[[Category: Membrane]]
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[[Category: Zebisch M]]
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[[Category: R-spo]]
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[[Category: Receptor]]
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[[Category: Rnf43]]
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[[Category: Rspo]]
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[[Category: Rspo1]]
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[[Category: Rspo3]]
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[[Category: Rspo4]]
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[[Category: Signaling protein]]
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[[Category: Signalling]]
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[[Category: Wnt]]
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[[Category: Znrf3]]
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Current revision

Xenopus RSPO2 Fu1-Fu2 crystal form I

PDB ID 4c8v

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