4jjh

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{{STRUCTURE_4jjh| PDB=4jjh | SCENE= }}
 
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===Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]===
 
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==Disease==
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==Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]==
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[[http://www.uniprot.org/uniprot/PVRL4_HUMAN PVRL4_HUMAN]] Ectodermal dysplasia - syndactyly syndrome. Defects in PVRL4 are the cause of ectodermal dysplasia-syndactyly syndrome type 1 (EDSS1) [MIM:[http://omim.org/entry/613573 613573]]. EDSS1 is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating.<ref>PMID:20691405</ref>
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<StructureSection load='4jjh' size='340' side='right'caption='[[4jjh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jjh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JJH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jjh OCA], [https://pdbe.org/4jjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jjh RCSB], [https://www.ebi.ac.uk/pdbsum/4jjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jjh ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Ectodermal dysplasia-pili torti-cutaneous syndactyly syndrome. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NECT4_HUMAN NECT4_HUMAN] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.<ref>PMID:22048310</ref> <ref>PMID:23202587</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/PVRL4_HUMAN PVRL4_HUMAN]] Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
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== References ==
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==About this Structure==
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<references/>
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[[4jjh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JJH OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Homo sapiens]]
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<references group="xtra"/><references/>
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[[Category: Large Structures]]
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[[Category: Human]]
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[[Category: Ahmed M]]
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[[Category: Ahmed, M.]]
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[[Category: Almo SC]]
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[[Category: Almo, S C.]]
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[[Category: Banu R]]
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[[Category: Banu, R.]]
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[[Category: Bhosle R]]
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[[Category: Bhosle, R.]]
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[[Category: Bonanno J]]
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[[Category: Bonanno, J.]]
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[[Category: Calarese D]]
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[[Category: Calarese, D.]]
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[[Category: Celikigil A]]
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[[Category: Celikigil, A.]]
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[[Category: Chamala S]]
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[[Category: Chamala, S.]]
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[[Category: Chan MK]]
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[[Category: Chan, M K.]]
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[[Category: Chowdhury S]]
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[[Category: Chowdhury, S.]]
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[[Category: Fiser A]]
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[[Category: Fiser, A.]]
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[[Category: Garforth S]]
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[[Category: Garforth, S.]]
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[[Category: Glenn AS]]
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[[Category: Glenn, A S.]]
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[[Category: Hillerich B]]
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[[Category: Hillerich, B.]]
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[[Category: Khafizov K]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]]
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[[Category: Kumar PR]]
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[[Category: Khafizov, K.]]
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[[Category: Love J]]
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[[Category: Kumar, P R.]]
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[[Category: Nathenson SG]]
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[[Category: Love, J.]]
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[[Category: Patel H]]
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[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
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[[Category: Seidel R]]
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[[Category: Nathenson, S G.]]
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[[Category: Stead M]]
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[[Category: Patel, H.]]
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[[Category: Toro R]]
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[[Category: Seidel, R.]]
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[[Category: Stead, M.]]
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[[Category: Toro, R.]]
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[[Category: Atoms-to-animals: the immune function network]]
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[[Category: Cell adhesion]]
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[[Category: Ifn]]
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[[Category: Ig superfamily]]
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[[Category: Ig-like d1 domain]]
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[[Category: Immune system]]
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[[Category: Nectin-4]]
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[[Category: New york structural genomics research consortium]]
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[[Category: Nysgrc]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of the D1 domain from human Nectin-4 extracellular fragment [PSI-NYSGRC-005624]

PDB ID 4jjh

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