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4jkv

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{{STRUCTURE_4jkv| PDB=4jkv | SCENE= }}
 
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===Structure of the human smoothened 7TM receptor in complex with an antitumor agent===
 
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{{ABSTRACT_PUBMED_23636324}}
 
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==Function==
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==Structure of the human smoothened 7TM receptor in complex with an antitumor agent==
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[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
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<StructureSection load='4jkv' size='340' side='right'caption='[[4jkv]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4jkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JKV FirstGlance]. <br>
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[[4jkv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKV OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KS:4-FLUORO-N-METHYL-N-{1-[4-(1-METHYL-1H-PYRAZOL-5-YL)PHTHALAZIN-1-YL]PIPERIDIN-4-YL}-2-(TRIFLUOROMETHYL)BENZAMIDE'>1KS</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkv OCA], [https://pdbe.org/4jkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jkv RCSB], [https://www.ebi.ac.uk/pdbsum/4jkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkv ProSAT]</span></td></tr>
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<ref group="xtra">PMID:023636324</ref><references group="xtra"/><references/>
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</table>
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[[Category: Bacillus coli migula 1895]]
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== Function ==
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[[Category: Cherezov, V.]]
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[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
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[[Category: GPCR, GPCR Network.]]
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== References ==
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[[Category: Han, G W.]]
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<references/>
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[[Category: Huang, X.]]
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__TOC__
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[[Category: Katritch, V.]]
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</StructureSection>
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[[Category: Liu, W.]]
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[[Category: Escherichia coli]]
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[[Category: Roth, B L.]]
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[[Category: Homo sapiens]]
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[[Category: Siu, F Y.]]
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[[Category: Large Structures]]
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[[Category: Stevens, R C.]]
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[[Category: Cherezov V]]
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[[Category: Wang, C.]]
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[[Category: Han GW]]
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[[Category: Wu, H.]]
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[[Category: Huang X]]
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[[Category: Antitumor agent]]
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[[Category: Katritch V]]
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[[Category: Gpcr]]
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[[Category: Liu W]]
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[[Category: Gpcr network]]
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[[Category: Roth BL]]
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[[Category: Human smoothened receptor]]
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[[Category: Siu FY]]
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[[Category: Membrane]]
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[[Category: Stevens RC]]
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[[Category: Membrane protein]]
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[[Category: Wang C]]
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[[Category: Novel protein engineering]]
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[[Category: Wu H]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Structure of the human smoothened 7TM receptor in complex with an antitumor agent

PDB ID 4jkv

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