4jar
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- | {{STRUCTURE_4jar| PDB=4jar | SCENE= }} | ||
- | ===Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES=== | ||
- | {{ABSTRACT_PUBMED_23615910}} | ||
- | == | + | ==Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES== |
- | [[ | + | <StructureSection load='4jar' size='340' side='right'caption='[[4jar]], [[Resolution|resolution]] 1.98Å' scene=''> |
- | + | == Structural highlights == | |
- | == | + | <table><tr><td colspan='2'>[[4jar]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JAR FirstGlance]. <br> |
- | [[4jar]] is a 4 chain structure with sequence from [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.98Å</td></tr> |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jar OCA], [https://pdbe.org/4jar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jar RCSB], [https://www.ebi.ac.uk/pdbsum/4jar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jar ProSAT]</span></td></tr> | |
- | == | + | </table> |
- | < | + | == Function == |
- | [ | + | [https://www.uniprot.org/uniprot/PKS11_MYCTU PKS11_MYCTU] Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products. |
- | [ | + | __TOC__ |
- | [ | + | </StructureSection> |
- | [ | + | [[Category: Large Structures]] |
- | [ | + | [[Category: Mycobacterium tuberculosis]] |
- | [[Category: | + | [[Category: Gokulan K]] |
- | [[Category: | + | [[Category: Sacchettini JC]] |
- | [[Category: | + | |
- | [[Category: | + |
Current revision
Crystal structure of mycobacterium tuberculosis pks11 in complex with polyketide intermediates and evidence that it synthesize ALKYLPYRONES
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