4c99

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{{STRUCTURE_4c99| PDB=4c99 | SCENE= }}
 
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===Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I===
 
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{{ABSTRACT_PUBMED_24225776}}
 
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==Function==
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==Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I==
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[[http://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref> [[http://www.uniprot.org/uniprot/RSPO2_MOUSE RSPO2_MOUSE]] Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors.<ref>PMID:21693646</ref>
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<StructureSection load='4c99' size='340' side='right'caption='[[4c99]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4c99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C99 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c99 OCA], [https://pdbe.org/4c99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c99 RCSB], [https://www.ebi.ac.uk/pdbsum/4c99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c99 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/ZNRF3_MOUSE ZNRF3_MOUSE]] E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.<ref>PMID:22575959</ref> <ref>PMID:22895187</ref>
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==About this Structure==
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==See Also==
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[[4c99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C99 OCA].
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024225776</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Lk3 transgenic mice]]
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</StructureSection>
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[[Category: Jones, E Y.]]
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[[Category: Large Structures]]
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[[Category: Zebisch, M.]]
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[[Category: Mus musculus]]
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[[Category: Lgr4]]
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[[Category: Jones EY]]
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[[Category: Lgr5]]
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[[Category: Zebisch M]]
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[[Category: Lgr6]]
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[[Category: Ligase-signaling protein complex]]
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[[Category: Membrane]]
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[[Category: R-spo]]
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[[Category: R-spondin]]
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[[Category: Receptor]]
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[[Category: Rnf43]]
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[[Category: Rspo]]
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[[Category: Rspo1]]
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[[Category: Rspo3]]
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[[Category: Rspo4]]
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[[Category: Signalling]]
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[[Category: Wnt]]
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Current revision

Mouse ZNRF3 ectodomain in complex with mouse RSPO2 Fu1-Fu2 crystal form I

PDB ID 4c99

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