4jir

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{{STRUCTURE_4jir| PDB=4jir | SCENE= }}
 
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===Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat===
 
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{{ABSTRACT_PUBMED_24100137}}
 
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==Function==
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==Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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<StructureSection load='4jir' size='340' side='right'caption='[[4jir]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jir]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JIR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPR:{5-[(2E)-2-METHYL-3-PHENYLPROP-2-EN-1-YLIDENE]-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL}ACETIC+ACID'>EPR</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jir OCA], [https://pdbe.org/4jir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jir RCSB], [https://www.ebi.ac.uk/pdbsum/4jir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jir ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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==About this Structure==
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==See Also==
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[[4jir]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIR OCA].
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024100137</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Aldehyde reductase]]
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[[Category: Large Structures]]
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[[Category: Human]]
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[[Category: Chen K]]
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[[Category: Chen, K.]]
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[[Category: Hu X]]
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[[Category: Hu, X.]]
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[[Category: Zhai J]]
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[[Category: Zhai, J.]]
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[[Category: Zhang H]]
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[[Category: Zhang, H..]]
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[[Category: Zhang L]]
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[[Category: Zhang, L.]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y.]]
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[[Category: Zheng X]]
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[[Category: Zheng, X.]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Tim barrel]]
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Current revision

Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Epalrestat

PDB ID 4jir

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