This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4nni
From Proteopedia
(Difference between revisions)
m (Protected "4nni" [edit=sysop:move=sysop]) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide== | |
| + | <StructureSection load='4nni' size='340' side='right'caption='[[4nni]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [https://pdbe.org/4nni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [https://www.ebi.ac.uk/pdbsum/4nni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Ribosomal protein S1|Ribosomal protein S1]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Cai Q]] | ||
| + | [[Category: Lin D]] | ||
| + | [[Category: Liu Y]] | ||
| + | [[Category: Yang J]] | ||
Current revision
Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide
| |||||||||||
