This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2qme

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:36, 30 August 2023) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2qme.gif|left|200px]]<br /><applet load="2qme" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2qme, resolution 1.75&Aring;" />
 
-
'''Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)'''<br />
 
-
==About this Structure==
+
==Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)==
-
2QME is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=GCP:'>GCP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA].
+
<StructureSection load='2qme' size='340' side='right'caption='[[2qme]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
[[Category: Homo sapiens]]
+
== Structural highlights ==
-
[[Category: Non-specific serine/threonine protein kinase]]
+
<table><tr><td colspan='2'>[[2qme]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QME OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QME FirstGlance]. <br>
-
[[Category: Protein complex]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
[[Category: Arrowsmith, C H.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[Category: Bunkoczi, G.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qme FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qme OCA], [https://pdbe.org/2qme PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qme RCSB], [https://www.ebi.ac.uk/pdbsum/2qme PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qme ProSAT]</span></td></tr>
-
[[Category: Burgess-Brown, N.]]
+
</table>
-
[[Category: Delft, F von.]]
+
== Function ==
-
[[Category: Doyle, D.]]
+
[https://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref>
-
[[Category: Edwards, A.]]
+
== Evolutionary Conservation ==
-
[[Category: Elkins, J M.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Knapp, S.]]
+
Check<jmol>
-
[[Category: SGC, Structural Genomics Consortium.]]
+
<jmolCheckbox>
-
[[Category: Sundstrom, M.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qme_consurf.spt"</scriptWhenChecked>
-
[[Category: Ugochukwu, E.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Weigelt, J.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Yang, X.]]
+
</jmolCheckbox>
-
[[Category: GCP]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qme ConSurf].
-
[[Category: GOL]]
+
<div style="clear:both"></div>
-
[[Category: MG]]
+
-
[[Category: allosteric enzyme]]
+
-
[[Category: alternative splicing]]
+
-
[[Category: apoptosis]]
+
-
[[Category: atp-binding]]
+
-
[[Category: cell junction]]
+
-
[[Category: cell projection]]
+
-
[[Category: crib]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: gtp-binding]]
+
-
[[Category: gtpase rac3]]
+
-
[[Category: kinase]]
+
-
[[Category: lipoprotein]]
+
-
[[Category: membrane]]
+
-
[[Category: methylation]]
+
-
[[Category: nucleotide-binding]]
+
-
[[Category: p21 rac]]
+
-
[[Category: phosphorylation]]
+
-
[[Category: prenylation]]
+
-
[[Category: ras-related c3 botulinum toxin substrate 3]]
+
-
[[Category: serine/threonine-protein kinase]]
+
-
[[Category: sgc]]
+
-
[[Category: signaling protein]]
+
-
[[Category: signaling protein/transferase complex]]
+
-
[[Category: small gtp binding protein]]
+
-
[[Category: structural genomics]]
+
-
[[Category: structural genomics consortium]]
+
-
[[Category: transferase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:40:26 2008''
+
==See Also==
 +
*[[Rac 3D structures|Rac 3D structures]]
 +
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith CH]]
 +
[[Category: Bunkoczi G]]
 +
[[Category: Burgess-Brown N]]
 +
[[Category: Doyle D]]
 +
[[Category: Edwards A]]
 +
[[Category: Elkins JM]]
 +
[[Category: Knapp S]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Ugochukwu E]]
 +
[[Category: Weigelt J]]
 +
[[Category: Yang X]]
 +
[[Category: Von Delft F]]

Current revision

Crystal structure of human RAC3 in complex with CRIB domain of human p21-activated kinase 1 (PAK1)

PDB ID 2qme

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qme"
Personal tools