4mr5

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{{STRUCTURE_4mr5| PDB=4mr5 | SCENE= }}
 
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===Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH)===
 
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{{ABSTRACT_PUBMED_24248379}}
 
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==Function==
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==Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH)==
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[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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<StructureSection load='4mr5' size='340' side='right'caption='[[4mr5]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4mr5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MR5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1K0:2-[4-(2-HYDROXYETHOXY)-3,5-DIMETHYLPHENYL]-5,7-DIMETHOXYQUINAZOLIN-4(3H)-ONE'>1K0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mr5 OCA], [https://pdbe.org/4mr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mr5 RCSB], [https://www.ebi.ac.uk/pdbsum/4mr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mr5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
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==About this Structure==
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==See Also==
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[[4mr5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MR5 OCA].
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024248379</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Arrowsmith, C H.]]
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</StructureSection>
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[[Category: Bountra, C.]]
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[[Category: Homo sapiens]]
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[[Category: Delft, F von.]]
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[[Category: Large Structures]]
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[[Category: Edwards, A M.]]
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[[Category: Arrowsmith CH]]
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[[Category: Fedorov, O.]]
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[[Category: Bountra C]]
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[[Category: Felletar, I.]]
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[[Category: Edwards AM]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Fedorov O]]
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[[Category: Knapp, S.]]
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[[Category: Felletar I]]
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[[Category: Martin, S.]]
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[[Category: Filippakopoulos P]]
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[[Category: Picaud, S.]]
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[[Category: Knapp S]]
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[[Category: Weigelt, J.]]
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[[Category: Martin S]]
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[[Category: Brd2]]
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[[Category: Picaud S]]
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[[Category: Inhibitor complex]]
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[[Category: Weigelt J]]
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[[Category: Ring3]]
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[[Category: Von Delft F]]
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[[Category: Rvx-oh]]
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[[Category: Sgc]]
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[[Category: Small molecule inhibitor]]
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[[Category: Structural genomics consortium]]
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[[Category: Transcription-transcription inhibitor complex]]
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Current revision

Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-OH)

PDB ID 4mr5

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