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4i1n

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{{STRUCTURE_4i1n| PDB=4i1n | SCENE= }}
 
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===R104A-ca1697 nanobody binding to the binary DHFR.folate complex===
 
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==Function==
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==R104A-ca1697 nanobody binding to the binary DHFR.folate complex==
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[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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<StructureSection load='4i1n' size='340' side='right'caption='[[4i1n]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i1n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1n OCA], [https://pdbe.org/4i1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1n RCSB], [https://www.ebi.ac.uk/pdbsum/4i1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1n ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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==About this Structure==
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==See Also==
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[[4i1n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1N OCA].
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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[[Category: Dihydrofolate reductase]]
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__TOC__
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[[Category: Barlow, J N.]]
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</StructureSection>
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[[Category: Oyen, D.]]
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[[Category: Escherichia coli K-12]]
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[[Category: Steyaert, J.]]
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[[Category: Lama glama]]
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[[Category: Alpha/beta fold]]
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[[Category: Large Structures]]
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[[Category: Folate derivative]]
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[[Category: Barlow JN]]
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[[Category: Hydride transfer]]
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[[Category: Oyen D]]
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[[Category: Immunoglobulin fold]]
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[[Category: Steyaert J]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase-immune system complex]]
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[[Category: Reductase]]
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Current revision

R104A-ca1697 nanobody binding to the binary DHFR.folate complex

PDB ID 4i1n

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