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2qq0

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[[Image:2qq0.gif|left|200px]]<br /><applet load="2qq0" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2qq0, resolution 1.50&Aring;" />
 
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'''Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp'''<br />
 
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==About this Structure==
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==Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp==
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2QQ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=THM:'>THM</scene>, <scene name='pdbligand=TMP:'>TMP</scene>, <scene name='pdbligand=ANP:'>ANP</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQ0 OCA].
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<StructureSection load='2qq0' size='340' side='right'caption='[[2qq0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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[[Category: Single protein]]
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== Structural highlights ==
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[[Category: Thermotoga maritima]]
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<table><tr><td colspan='2'>[[2qq0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QQ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QQ0 FirstGlance]. <br>
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[[Category: Thymidine kinase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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[[Category: Konrad, M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene>, <scene name='pdbligand=TMP:THYMIDINE-5-PHOSPHATE'>TMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Lavie, A.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qq0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qq0 OCA], [https://pdbe.org/2qq0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qq0 RCSB], [https://www.ebi.ac.uk/pdbsum/2qq0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qq0 ProSAT]</span></td></tr>
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[[Category: Lichter, J.]]
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</table>
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[[Category: Lutz, S.]]
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== Function ==
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[[Category: Segura-Pena, D.]]
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[https://www.uniprot.org/uniprot/KITH_THEMA KITH_THEMA]
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[[Category: Trani, M.]]
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== Evolutionary Conservation ==
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[[Category: ADP]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: ANP]]
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Check<jmol>
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[[Category: MG]]
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<jmolCheckbox>
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[[Category: THM]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qq/2qq0_consurf.spt"</scriptWhenChecked>
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[[Category: TMP]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: ZN]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: appnhp]]
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</jmolCheckbox>
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[[Category: atp-binding]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qq0 ConSurf].
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[[Category: cytoplasm]]
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<div style="clear:both"></div>
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[[Category: dna synthesis]]
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[[Category: nucleotide-binding]]
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[[Category: open-conformation]]
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[[Category: thymidine kinase]]
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[[Category: tmtk]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:15 2008''
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==See Also==
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*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Thermotoga maritima]]
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[[Category: Konrad M]]
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[[Category: Lavie A]]
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[[Category: Lichter J]]
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[[Category: Lutz S]]
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[[Category: Segura-Pena D]]
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[[Category: Trani M]]

Current revision

Thymidine Kinase from Thermotoga Maritima in complex with thymidine + AppNHp

PDB ID 2qq0

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