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4map

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{{STRUCTURE_4map| PDB=4map | SCENE= }}
 
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===Crystal structure of Ara h 8 purified with heating===
 
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==About this Structure==
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==Crystal structure of Ara h 8 purified with heating==
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[[4map]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAP OCA].
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<StructureSection load='4map' size='340' side='right'caption='[[4map]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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[[Category: Chruszcz, M.]]
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== Structural highlights ==
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[[Category: Hurlburt, B K.]]
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<table><tr><td colspan='2'>[[4map]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arachis_hypogaea Arachis hypogaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MAP FirstGlance]. <br>
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[[Category: Majorek, K A.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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[[Category: Maleki, S J.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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[[Category: McBride, J K.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4map FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4map OCA], [https://pdbe.org/4map PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4map RCSB], [https://www.ebi.ac.uk/pdbsum/4map PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4map ProSAT]</span></td></tr>
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[[Category: Offermann, L R.]]
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</table>
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[[Category: Bet v 1 like]]
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== Function ==
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[[Category: Plant protein]]
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[https://www.uniprot.org/uniprot/Q6VT83_ARAHY Q6VT83_ARAHY]
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[[Category: Small molecule carrier]]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The incidence of peanut allergy continues to rise in the United States and Europe. Whereas exposure to the major allergens Ara h 1, 2, 3, and 6 can cause fatal anaphylaxis, exposure to the minor allergens usually does not. Ara h 8 is a minor allergen. Importantly, it is the minor food allergens that are thought to be responsible for oral allergy syndrome (OAS), in which sensitization to airborne allergens causes a Type 2 allergic reaction to ingested foods. Furthermore, it is believed that similar protein structure rather than a similar linear sequence is the cause of OAS. Bet v 1 from birch pollen is a common sensitizing agent, and OAS results when patients consume certain fruits, vegetables, tree nuts, and peanuts. Here, we report the three-dimensional structure of Ara h 8, a Bet v 1 homolog. The overall fold is very similar to that of Bet v 1, Api g 1 (celery), Gly m 4 (soy), and Pru av 1 (cherry). Ara h 8 binds the isoflavones quercetin and apigenin as well as resveratrol avidly.
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Structure and Function of the Peanut Panallergen Ara h 8.,Hurlburt BK, Offermann LR, McBride JK, Majorek KA, Maleki SJ, Chruszcz M J Biol Chem. 2013 Dec 27;288(52):36890-901. doi: 10.1074/jbc.M113.517797. Epub, 2013 Nov 19. PMID:24253038<ref>PMID:24253038</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4map" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arachis hypogaea]]
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[[Category: Large Structures]]
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[[Category: Chruszcz M]]
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[[Category: Hurlburt BK]]
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[[Category: Majorek KA]]
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[[Category: Maleki SJ]]
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[[Category: McBride JK]]
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[[Category: Offermann LR]]

Current revision

Crystal structure of Ara h 8 purified with heating

PDB ID 4map

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