2clp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:20, 13 December 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_2clp| PDB=2clp | SCENE= }}
 
-
===Crystal structure of human aflatoxin B1 aldehyde reductase member 3===
 
-
==About this Structure==
+
==Crystal structure of human aflatoxin B1 aldehyde reductase member 3==
-
[[2clp]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLP OCA].
+
<StructureSection load='2clp' size='340' side='right'caption='[[2clp]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
[[Category: Human]]
+
== Structural highlights ==
-
[[Category: Arrowsmith, C.]]
+
<table><tr><td colspan='2'>[[2clp]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CLP FirstGlance]. <br>
-
[[Category: Debreczeni, J E.]]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
[[Category: Delft, F von.]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-
[[Category: Edwards, A.]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2clp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2clp OCA], [https://pdbe.org/2clp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2clp RCSB], [https://www.ebi.ac.uk/pdbsum/2clp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2clp ProSAT]</span></td></tr>
-
[[Category: Gileadi, O.]]
+
</table>
-
[[Category: Guo, K.]]
+
== Function ==
-
[[Category: Johansson, C.]]
+
[https://www.uniprot.org/uniprot/ARK73_HUMAN ARK73_HUMAN] Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<ref>PMID:18416522</ref>
-
[[Category: Kavanagh, K.]]
+
== Evolutionary Conservation ==
-
[[Category: Marsden, B D.]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Oppermann, U.]]
+
Check<jmol>
-
[[Category: Papagrigoriou, E.]]
+
<jmolCheckbox>
-
[[Category: Smee, C.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2clp_consurf.spt"</scriptWhenChecked>
-
[[Category: Sundstrom, M.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Turnbull, A.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Weigelt, J.]]
+
</jmolCheckbox>
-
[[Category: Aldo-keto reductase family 7]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2clp ConSurf].
-
[[Category: Nad]]
+
<div style="clear:both"></div>
-
[[Category: Nadp]]
+
== References ==
-
[[Category: Oxidoreductase]]
+
<references/>
-
[[Category: Ssa reductase]]
+
__TOC__
-
[[Category: Tim barrel]]
+
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Arrowsmith C]]
 +
[[Category: Debreczeni JE]]
 +
[[Category: Edwards A]]
 +
[[Category: Gileadi O]]
 +
[[Category: Guo K]]
 +
[[Category: Johansson C]]
 +
[[Category: Kavanagh K]]
 +
[[Category: Marsden BD]]
 +
[[Category: Oppermann U]]
 +
[[Category: Papagrigoriou E]]
 +
[[Category: Smee C]]
 +
[[Category: Sundstrom M]]
 +
[[Category: Turnbull A]]
 +
[[Category: Weigelt J]]
 +
[[Category: Von Delft F]]

Current revision

Crystal structure of human aflatoxin B1 aldehyde reductase member 3

PDB ID 2clp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2clp"
Personal tools