4jh9

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{{STRUCTURE_4jh9| PDB=4jh9 | SCENE= }}
 
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===Crystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin Product===
 
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{{ABSTRACT_PUBMED_24004181}}
 
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==Function==
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==Crystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin Product==
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[[http://www.uniprot.org/uniprot/FOSB_BACC1 FOSB_BACC1]] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).
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<StructureSection load='4jh9' size='340' side='right'caption='[[4jh9]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4jh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_ATCC_10987 Bacillus cereus ATCC 10987]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JH9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1KM:(2R)-2-AZANYL-3-[(1R,2S)-2-OXIDANYL-1-PHOSPHONO-PROPYL]SULFANYL-PROPANOIC+ACID'>1KM</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jh9 OCA], [https://pdbe.org/4jh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jh9 RCSB], [https://www.ebi.ac.uk/pdbsum/4jh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jh9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FOSB_BACC1 FOSB_BACC1] Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity).
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==About this Structure==
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==See Also==
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[[4jh9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacc1 Bacc1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JH9 OCA].
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*[[Metallothiol transferase FosB|Metallothiol transferase FosB]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024004181</ref><references group="xtra"/><references/>
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[[Category: Bacillus cereus ATCC 10987]]
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[[Category: Bacc1]]
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[[Category: Large Structures]]
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[[Category: Armstrong, R N.]]
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[[Category: Armstrong RN]]
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[[Category: Cook, P D.]]
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[[Category: Cook PD]]
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[[Category: Harp, J.]]
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[[Category: Harp J]]
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[[Category: Jagessar, K.]]
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[[Category: Jagessar K]]
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[[Category: Keithly, M E.]]
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[[Category: Keithly ME]]
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[[Category: Thompson, M K.]]
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[[Category: Thompson MK]]
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[[Category: Bacillithiol-s-transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of FosB from Bacillus cereus with Maganese and Potential BSH-Fosfomycin Product

PDB ID 4jh9

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