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2w4q
From Proteopedia
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| - | {{STRUCTURE_2w4q| PDB=2w4q | SCENE= }} | ||
| - | ===Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid=== | ||
| - | == | + | ==Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid== |
| - | [[2w4q]] is a 1 chain structure with sequence from [ | + | <StructureSection load='2w4q' size='340' side='right'caption='[[2w4q]], [[Resolution|resolution]] 2.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2w4q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBW:(3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC+ACID'>CBW</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4q OCA], [https://pdbe.org/2w4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4q RCSB], [https://www.ebi.ac.uk/pdbsum/2w4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTGR2_HUMAN PTGR2_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity).<ref>PMID:19000823</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w4q_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4q ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Alcohol dehydrogenase|Alcohol dehydrogenase]] | + | *[[Alcohol dehydrogenase 3D structures|Alcohol dehydrogenase 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Arrowsmith | + | __TOC__ |
| - | [[Category: Bountra | + | </StructureSection> |
| - | [[Category: Edwards | + | [[Category: Homo sapiens]] |
| - | [[Category: Niesen | + | [[Category: Large Structures]] |
| - | [[Category: Oppermann | + | [[Category: Arrowsmith C]] |
| - | [[Category: Picaud | + | [[Category: Bountra C]] |
| - | [[Category: Shafqat | + | [[Category: Edwards A]] |
| - | [[Category: Ugochukwu | + | [[Category: Niesen F]] |
| - | [[Category: Weigelt | + | [[Category: Oppermann U]] |
| - | [[Category: Yue | + | [[Category: Picaud S]] |
| - | + | [[Category: Shafqat N]] | |
| - | + | [[Category: Ugochukwu E]] | |
| - | + | [[Category: Weigelt J]] | |
| - | + | [[Category: Yue WW]] | |
Current revision
Crystal structure of human zinc-binding alcohol dehydrogenase 1 (ZADH1) in ternary complex with NADP and 18beta-glycyrrhetinic acid
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bountra C | Edwards A | Niesen F | Oppermann U | Picaud S | Shafqat N | Ugochukwu E | Weigelt J | Yue WW
