2ma9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==HIV-1 Vif SOCS-box and Elongin BC solution structure== | |
| + | <StructureSection load='2ma9' size='340' side='right'caption='[[2ma9]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ma9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(NEW_YORK-5_ISOLATE) Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MA9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ma9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma9 OCA], [https://pdbe.org/2ma9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ma9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ma9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ma9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VIF_HV1N5 VIF_HV1N5] Counteracts the innate antiviral activity of human APOBEC3F and APOBEC3G. Forms a complex with host APOBEC3F and APOBEC3G thus preventing the entry of these lethally hypermutating enzymes into progeny virions. Recruits an active E3 ubiquitin ligase complex composed of elongin BC, CUL5, and RBX2 to induce polyubiquitination of APOBEC3G and APOBEC3F. In turn, they are directed to the 26S proteasome for degradation. Vif interaction with APOBEC3G also blocks its cytidine deaminase activity in a proteasome-independent manner, suggesting a dual inhibitory mechanism. May interact directly with APOBEC3G mRNA in order to inhibit its translation. Seems to play a role in viral morphology by affecting the stability of the viral nucleoprotein core. Finally, Vif also contributes to the G2 cell cycle arrest observed in HIV infected cells (By similarity).<ref>PMID:8184544</ref> <ref>PMID:14557625</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Elongation factor 3D structures|Elongation factor 3D structures]] | |
| - | + | *[[Virion infectivity factor|Virion infectivity factor]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Atkinson RA]] | ||
| + | [[Category: Bergeron JR]] | ||
| + | [[Category: Lu Z]] | ||
| + | [[Category: Malim MH]] | ||
| + | [[Category: Matthews SJ]] | ||
| + | [[Category: Oregioni A]] | ||
| + | [[Category: Sanderson MR]] | ||
| + | [[Category: Schaller T]] | ||
| + | [[Category: Veselkov DA]] | ||
| + | [[Category: Yang Y]] | ||
Current revision
HIV-1 Vif SOCS-box and Elongin BC solution structure
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Categories: Homo sapiens | Large Structures | Atkinson RA | Bergeron JR | Lu Z | Malim MH | Matthews SJ | Oregioni A | Sanderson MR | Schaller T | Veselkov DA | Yang Y
