Clathrin

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{{STRUCTURE_3lvg| PDB=3lvg | SIZE=400| SCENE= |right|CAPTION=Bovine clathrin heavy (grey, green, pink) and light (yellow, magenta, cyan) chains, [[3lvg]] }}
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<StructureSection load='3lvg' size='350' side='right' caption='Bovine clathrin heavy (darkmagenta, magenta, violet) and light (yellow, green, cyan) chains (PDB entry [[3lvg]])' scene='46/465441/Cv/1'>
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'''Clathrin''' (CLT) is a component of vesicle coast. It is composed of 3 heavy chains (Hc) and 3 light chains (Lc) interacting in their C-termini and forming a triskelion. The Hc domains are: N-terminal, ankle, distal leg, knee, proximal leg and trimerization.
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'''Clathrin''' (CLT) is a component of vesicle coats.<ref>PMID:1063406</ref> For details see [[Clathrin JMU]].
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{{TOC limit|limit=2}}
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== Structural highlights ==
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== 3D Structures of Clathrin ==
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Clathrin is composed of <scene name='46/465441/Cv/2'>3 heavy chains (Hc) and 3 light chains (Lc) interacting in their C-termini and forming a triskelion</scene>. <ref>PMID:20493816</ref> The Hc domains are: N-terminal, ankle, distal leg, knee, proximal leg and trimerization.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[FirstGlance/Virus_Capsids_and_Other_Large_Assemblies#Clathrin_Coat|Clathrin Coat]] shows a small, empty clathrin coat assembly of triskelions from an electron microscopic structure, [[3iyv]].
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[[1bpo]] – rCLT Hc N terminal domain + linker – rat<br />
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== 3D Structures of Clathrin ==
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[[1b89]] – bCLT Hc proximal leg – bovine<br />
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[[Clathrin 3D structures]]
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[[3qil]] - bCLT Hc trimerization domain<br />
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[[3lvg]] - bCLT Hc + Lc<br />
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[[3lvh]] - bCLT Hc HUB fragment + Lc <br />
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[[1xi4]], [[3iyv]] – bCLT Hc + Lc – Cryo EM
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===Clathrin binary complexes===
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[[1c9i]], [[1c9l]] - rCLT Hc N terminal + B-adaptin 3<br />
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</StructureSection>
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[[2xzg]], [[2xzh]], [[4g55]]- CLT Hc N terminal + pitstop inhibitor - human<br />
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[[1utc]] - bCLT Hc N terminal + amphiphysin peptide<br />
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[[1xi5]] - bCLT Hc + auxilin J-domain – Cryo EM<br />
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[[3gc3]] – bCLT Hc WD domain + b-arrestin-1<br />
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[[3gd1]] - bCLT Hc + Hc WD domain + b-arrest
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Bovine clathrin heavy (darkmagenta, magenta, violet) and light (yellow, green, cyan) chains (PDB entry 3lvg)

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References

  1. ↑ Pearse BM. Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1255-9. PMID:1063406
  2. ↑ Wilbur JD, Hwang PK, Ybe JA, Lane M, Sellers BD, Jacobson MP, Fletterick RJ, Brodsky FM. Conformation switching of clathrin light chain regulates clathrin lattice assembly. Dev Cell. 2010 May 18;18(5):841-8. PMID:20493816 doi:10.1016/j.devcel.2010.04.007

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Eric Martz

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