2r9n

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[[Image:2r9n.jpg|left|200px]]<br /><applet load="2r9n" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2r9n, resolution 2.00&Aring;" />
 
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'''Cathepsin S complexed with Compound 26'''<br />
 
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==About this Structure==
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==Cathepsin S complexed with Compound 26==
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2R9N is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=Y14:'>Y14</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9N OCA].
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<StructureSection load='2r9n' size='340' side='right'caption='[[2r9n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Cathepsin S]]
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== Structural highlights ==
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[[Category: Homo sapiens]]
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<table><tr><td colspan='2'>[[2r9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R9N FirstGlance]. <br>
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[[Category: Single protein]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Bekkali, Y.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y14:N-[(1S)-2-{[(3S)-1-BENZYL-3-CYANOPYRROLIDIN-3-YL]AMINO}-1-(CYCLOHEXYLMETHYL)-2-OXOETHYL]MORPHOLINE-4-CARBOXAMIDE'>Y14</scene></td></tr>
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[[Category: Brown, M L.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r9n OCA], [https://pdbe.org/2r9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r9n RCSB], [https://www.ebi.ac.uk/pdbsum/2r9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r9n ProSAT]</span></td></tr>
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[[Category: Capolino, A.]]
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</table>
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[[Category: Crane, K M.]]
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== Function ==
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[[Category: DeTuri, M.]]
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[[Category: Emmanuel, M J.]]
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== Evolutionary Conservation ==
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[[Category: Freeman, D.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Frye, L L.]]
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Check<jmol>
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[[Category: Girardot, M.]]
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<jmolCheckbox>
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[[Category: Grygon, C A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/2r9n_consurf.spt"</scriptWhenChecked>
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[[Category: Hao, M H.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Hrapchak, M.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Labadia, M E.]]
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</jmolCheckbox>
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[[Category: Liu, W.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r9n ConSurf].
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[[Category: Morwick, T.]]
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<div style="clear:both"></div>
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[[Category: Nelson, R.]]
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[[Category: Peterson, J D.]]
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[[Category: Raymond, E L.]]
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[[Category: Spero, D M.]]
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[[Category: Thomson, D S.]]
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[[Category: Wang, Y.]]
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[[Category: Ward, Y D.]]
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[[Category: White, A.]]
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[[Category: White, D M.]]
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[[Category: Wildeson, J.]]
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[[Category: Young, E R.R.]]
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[[Category: Zindell, R.]]
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[[Category: Y14]]
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[[Category: cathepsin]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: lysosome]]
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[[Category: polymorphism]]
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[[Category: protease]]
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[[Category: thiol protease]]
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[[Category: zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:45:41 2008''
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bekkali Y]]
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[[Category: Brown ML]]
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[[Category: Capolino A]]
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[[Category: Crane KM]]
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[[Category: DeTuri M]]
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[[Category: Emmanuel MJ]]
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[[Category: Freeman D]]
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[[Category: Frye LL]]
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[[Category: Girardot M]]
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[[Category: Grygon CA]]
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[[Category: Hao M-H]]
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[[Category: Hrapchak M]]
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[[Category: Labadia ME]]
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[[Category: Liu W]]
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[[Category: Morwick T]]
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[[Category: Nelson R]]
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[[Category: Peterson JD]]
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[[Category: Raymond EL]]
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[[Category: Spero DM]]
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[[Category: Thomson DS]]
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[[Category: Wang Y]]
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[[Category: Ward YD]]
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[[Category: White A]]
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[[Category: White DM]]
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[[Category: Wildeson J]]
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[[Category: Young ERR]]
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[[Category: Zindell R]]

Current revision

Cathepsin S complexed with Compound 26

PDB ID 2r9n

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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