3vyj

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{{STRUCTURE_3vyj| PDB=3vyj | SCENE= }}
 
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===Crystal structure of C-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)===
 
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{{ABSTRACT_PUBMED_24108122}}
 
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==About this Structure==
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==Crystal structure of C-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)==
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[[3vyj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VYJ OCA].
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<StructureSection load='3vyj' size='340' side='right'caption='[[3vyj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3vyj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VYJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vyj OCA], [https://pdbe.org/3vyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vyj RCSB], [https://www.ebi.ac.uk/pdbsum/3vyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vyj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5YIR8_MOUSE Q5YIR8_MOUSE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dendritic cell inhibitory receptor 2 (DCIR2) is a C-type lectin expressed on classical dendritic cells. We recently identified the unique ligand specificity of mouse DCIR2 (mDCIR2) toward biantennary complex-type glycans containing bisecting N-acetylglucosamine (GlcNAc). Here, we report the crystal structures of the mDCIR2 carbohydrate recognition domain in unliganded form as well as in complex with an agalactosylated complex-type N-glycan unit carrying a bisecting GlcNAc residue. Bisecting GlcNAc and the alpha1-3 branch of the biantennary oligosaccharide asymmetrically interact with canonical and non-canonical mDCIR2 residues. Ligand-protein interactions occur directly through mDCIR2-characteristic amino acid residues as well as via a calcium ion and water molecule. Our structural and biochemical data elucidate for the first time the unique binding mode of mDCIR2 for bisecting GlcNAc-containing glycans, a mode that contrasts sharply with that of other immune C-type lectin receptors such as DC-SIGN.
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==Reference==
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Recognition of Bisecting N-Acetylglucosamine: STRUCTURAL BASIS FOR ASYMMETRIC INTERACTION WITH THE MOUSE LECTIN DENDRITIC CELL INHIBITORY RECEPTOR 2.,Nagae M, Yamanaka K, Hanashima S, Ikeda A, Morita-Matsumoto K, Satoh T, Matsumoto N, Yamamoto K, Yamaguchi Y J Biol Chem. 2013 Nov 22;288(47):33598-610. doi: 10.1074/jbc.M113.513572. Epub, 2013 Oct 9. PMID:24108122<ref>PMID:24108122</ref>
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<ref group="xtra">PMID:024108122</ref><references group="xtra"/><references/>
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[[Category: Lk3 transgenic mice]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Hanashima, S.]]
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</div>
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[[Category: Ikeda, A.]]
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<div class="pdbe-citations 3vyj" style="background-color:#fffaf0;"></div>
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[[Category: Matsumoto, N.]]
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== References ==
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[[Category: Nagae, M.]]
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<references/>
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[[Category: Satoh, T.]]
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__TOC__
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[[Category: Yamaguchi, Y.]]
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</StructureSection>
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[[Category: Yamamoto, K.]]
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[[Category: Large Structures]]
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[[Category: Yamanaka, K.]]
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[[Category: Mus musculus]]
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[[Category: C-type lectin fold]]
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[[Category: Hanashima S]]
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[[Category: Carbohydrate binding protein]]
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[[Category: Ikeda A]]
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[[Category: Cell surface]]
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[[Category: Matsumoto N]]
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[[Category: Nagae M]]
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[[Category: Satoh T]]
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[[Category: Yamaguchi Y]]
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[[Category: Yamamoto K]]
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[[Category: Yamanaka K]]

Current revision

Crystal structure of C-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)

PDB ID 3vyj

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